当归散对小鼠低容受性子宫内膜孕激素受体和整合素β_3表达的影响  

Effects of DGS on the molecular markers of endometrial receptivity

作　　者：杨桢[1] 任慧利[2] 徐莉莉[3] 石玉迎[4] 李玲孺[1] 高琳[1] 

机构地区：[1]北京中医药大学,北京100029 [2]北京市朝阳中医院,北京100020 [3]复旦大学附属中山医院,上海200032 [4]卫生部中日友好医院,北京100029

出　　处：《中国中医基础医学杂志》2012年第4期386-388,共3页JOURNAL OF BASIC CHINESE MEDICINE

基　　金：国家自然科学基金资助项目(30801463);北京中医药大学自主选题项目(0100600056)

摘　　要：目的:探讨当归散及其拆方对低容受性子宫内膜PR和整合素β3表达的影响。方法:采用曲普瑞林注射制备小鼠模型,预防性给予受试液,于排卵后24h和48h测定子宫内膜中PR、整合素β3水平。结果:(1)PR的表达:48h时当归散组和归-芩组的PR表达明显上调,达到正常组水平(P>0.05);(2)整合素β3的表达:而当归散组和当归黄芩组整合素β3在2个时间点表达无显著差异,与正常组比较差异不显著(P>0.05)。结论:当归散和当归-黄芩能抑制曲普瑞林引起的PR过早下调,抑制整合素β3的提前表达,改善子宫内膜容受性。Objective： To examine the effects of DGS on the expressions of PR and Integrin β3 in mice with low endometrial receptivity induced by COH.Methods： The mice were treated by long-term COH with Triptorelin,and fed with the water solutions of Danggui Powder（DGS）,Danggui-Huangqin（GQ） and Chuanxiong-Baishao-Baizhu（QGQ）simultaneously.The expressions of PR and Integrin β3 in the endometrium were detected 24 and 48 hours after ovulation respectively.Results：（1） To 48 hours,the PR expression of Group DGS and Group GQ were significantly increased,and reached the control level（p0.05）.（2） Expression of Integrin β3： No significant increase was observed for either control group or Group DGS relative to that of 24hr and 48hr,and it was no significant difference between the two groups.Conclusions： DGS and GQ could inhibit the decrease of PR expression induced by COH,thereby inhibiting the Integrin β3 over-expression in the endometrium,in order to improve the endometrial receptivity.

关 键 词：当归散 孕激素受体 整合素Β3 子宫容受性 

分 类 号：R285.5[医药卫生—中药学]