普罗布考亚微乳剂的制备  

Preparation of Probucol Submicron Emulsions

作　　者：秦雪[1,2] 王成港[2] 任晓文[2] 

机构地区：[1]天津中医药大学,天津300193 [2]天津药物研究院释药技术与药代动力学国家重点实验室,天津300193

出　　处：《中国医药工业杂志》2012年第5期356-359,共4页Chinese Journal of Pharmaceuticals

摘　　要：以中链甘油三酯为油相,蛋黄卵磷脂和泊洛沙姆188为乳化剂,采用高压乳匀法制备普罗布考亚微乳剂。以平均粒径、多分散系数(PDI)、电位和稳定性等评价指标优化了处方。按优化条件制得的普罗布考亚微乳稳定性良好,平均粒径(168.8±1.5)nm,电位(-50.1±1.7)mV,载药量为(4.2±1.6)mg/ml。The probucol submicron emulsions were prepared by high pressure homogenization method.Medium chain triglyceride was used as oil phase,and egg yolk lecithin and poloxamer 188 were used as emulsifiers.The preparation was optimized with mean diameter,polydispersity index ζ potential and stability as indexes.The optimal product was stable,and the average particle size,ζ potential and drug loading were（168.8±1.5）nm,（-50.1±1.7）mV and（4.2±1.6）mg/ml,respectively.

关 键 词：普罗布考 亚微乳 制备 

分 类 号：R944.9[医药卫生—药剂学]