T细胞异常活化在系统性红斑狼疮中的分子免疫机制  

Molecular immunological mechanism of abnormal activated T cell in systemic lupus erythematosus

作　　者：赵海慧[1] 赵阴环[1] 

机构地区：[1]哈尔滨医科大学附属第二医院风湿免疫科

出　　处：《中国临床药理学与治疗学》2012年第4期452-457,共6页Chinese Journal of Clinical Pharmacology and Therapeutics

基　　金：黑龙江省自然科学基金(ZD200814-01)

摘　　要：系统性红斑狼疮(SLE)是一种系统性自身免疫性疾病,其发病机制错综复杂。T细胞参与SLE自身免疫的启动和整个过程,且直接促进SLE受累器官的病理改变。其活化异常引起的细胞因子产生失衡、自身反应性T细胞持续存在、T细胞凋亡增加等,在SLE发病机制中发挥关键的作用。本文就近年来发现的SLE患者中T细胞活化在细胞膜信号,胞内激酶和转录因子等各个水平的异常及其对SLE发生发展的影响加以综述。Systemic lupus erythematosus（SLE） is a systemic autoimmune disease,whose pathogenesis is very complicated.T cells contribute to the initiation and perpetuation of autoimmunity in SLE,and seem to be directly involved in the development of related organ pathology.Abnormal T cell activation could result in cytokine imbalance,the persistence of auto-reactive T cells,increased T cells apoptosis,these changes play pivotal role in SLE pathogenesis.This article presents an overview of the current research of abnormal T cell activation in SLE,include disorder of cell membrane signal,intracellular kinase,and transcription factor,and their effect on the occur and development of SLE.

关 键 词：系统性红斑狼疮 T细胞 T细胞活化 

分 类 号：R593.241[医药卫生—内科学]