阿托伐他汀对急性冠状动脉综合征患者血清可溶性细胞间粘附分子、内皮素和肿瘤坏死因子-α水平的影响  

Effect of atorvastatin on serum levels of sICAM-1 ,ET and TNF-α in patients with acute coronary syndromes

作　　者：齐玉霞 

机构地区：[1]山东省茌平县人民医院心内科,252100

出　　处：《中国实用医刊》2012年第10期47-48,共2页Chinese Journal of Practical Medicine

摘　　要：目的探讨阿托伐他汀对急性冠状动脉综合征患者血清可溶性细胞间粘附分子（sICAM-1）、内皮素（ET）和肿瘤坏死因子-α（TNF-α）的影响。方法选择急性冠状动脉综合征（Acs）患者80例，随机分为阿托伐汀治疗组和常规治疗组各40例。在治疗前及治疗后4周分别测定血清sICAM-1、ET和TNF-α水平并进行统计学比较。结果两组治疗前sICAM-1、ET和TNF-α水平比较差异无统计学意义（P〉0．05），两组治疗后血清sICAM-1、ET和TNF-α水平均较治疗前有所下降（P〈0．05），阿托伐他汀组治疗后较常规治疗组治疗后sICAM-1、ET和TNF-α水平明显降低，差异有统计学意义（P〈0．05）。结论sICAM-1、ET和TNF-α在ACS的发生机制中起着重要作用。阿托伐他汀能够降低该炎症因子水平并改善血管内皮功能，在ACS的治疗中具有重要作用。Objective To investigate the influence of atorvastatin on plasma sICAM-1, ET and TNF-α levels in patients with acute coronary syndrome （ACS）. Methods Eighty patients with ACS were randomly divided into two groups, patients in atorvas tatin group were treated with atorvastatin （n = 40） and patients in conventional treatment group were treated with routine therapy（ n = 40）. Plasma level of sICAM-1, ET and TNF-α of the two groups were measured before and after therapy. Results The baser line of sICAM-1, ET and TNF-α levels were not significantly different between two groups （P 〉 0. 05 ）. sICAM-1, ET and TNF-α levels in the two groups were significantly lower than those before treatment （P 〈 0. 05 ）. sICAM-1, ET and TNF-α levels in atorvastatin group were significantly lower than those in conventional treatment group after 4 weeks＇ treatment （ P 〈 0. 05）. Conclusions sICAM-1, TNF-α, ET participate in the pathogenesis of acute coronary syndrome. Atorvastatin has significant effect on inflam- matory reaction, can improve vascular endothelial functien and treat acute coronary syndrome preferably.

关 键 词：阿托伐他汀 急性冠脉综合征 SICAM-1 ET TNF-α 

分 类 号：R541.4[医药卫生—心血管疾病]