慢性阻塞性肺疾病患者血清干扰素-γ、肿瘤坏死因子-α和内皮素-1水平的表达和意义  

Expression and clinical significance of the serum Levels of IFN-γ, TNF-α and ET-1 in patients with chronic obstructive pulmonary disease

作　　者：刘晓云[1] 

机构地区：[1]济南市第一人民医院呼吸内科,250011

出　　处：《中国实用医刊》2012年第10期52-53,共2页Chinese Journal of Practical Medicine

摘　　要：目的探讨慢性阻塞性肺疾病（COPD）患者血清中干扰素-γ（IFN-γ）、肿瘤坏死因子-α（TNF-α）和内皮素-1（ET-1）的表达及意义。方法选择80例COPD患者作为研究对象，其中急性加重期40例，稳定期40例，另外选择30例健康体检者作为正常对照组，采用酶联免疫法（EHSA）分别检测血清中IFN-γ、TNF-α和ET-1的水平。结果COPD急性加重期和缓解期患者血清IFN-γTNF-α和ET-1的水平明显高于健康对照组（P〈0．05），COPD急性加重期IFN-γ、TNF-α和ET-1的水平明显高于缓解期患者（P〈0．05）。结论IFN-1、TNF—α和ET-1参与了COPD的发病机制，在COPD的发生及发展过程中可能起重要作用。检测IFN-γ、TNF-α和ET-1有助于COPD患者病情及预后的判断。Objective To investigate the expression and clinical significance of serum interfer- on-γ （IFN-γ） , tumor necrosis factor-α（TNF-α） and endothelin-1 （ET-1） levels in patients with chronic obstructive pulmonary disease （COPD）. Methods The serum was sampled and prepared from 80 cases of COPD （ exacerbation group 40 eases, remission group 40 cases） patients and 30 healthy persons. Serum level of IFN-γ, TNF-α and ET-1 were detected by ELISA. Results Levels of IFN-γ, TNF-α and ET-1 in the cases of COPD with stable stage and the period of AECOPD were higher than those of the healthy cases （ P 〈 0. 05 ）. Levels of IFN-γ, TNF-α and ET-1 in the period of AECOPD were higher than those in the cases of COPD with stable stage （P 〈 0. 05）. Conclusions IFN-γ, TNF-α and ET-1 participa- ted in the pathogenesis of COPD. Monitoring the changes of their serum levels is helpful for the manage- ment of the disease. And it probably can be a prognostic factor of COPD.

关 键 词：慢性阻塞性肺疾病 干扰素-Γ 肿瘤坏死因子-Α 内皮素-1 

分 类 号：R563.9[医药卫生—呼吸系统]