金属蛋白酶2基因-1306C/T多态性与冠心病的关系  

Correlation between matrix metalloproteinase-2 gene-1306C/T polymorphism and coronary artery disease

作　　者：徐峰[1] 金可可[1] 张怀勤[1] 徐力辛[1] 

机构地区：[1]温州医学院附属第一医院心血管内科,325000

出　　处：《实用医学杂志》2012年第10期1629-1631,共3页The Journal of Practical Medicine

摘　　要：目的:研究金属蛋白酶2(MMP-2)基因-1306C/T多态性与冠心病(CAD)发病的相关性。方法:采用基质辅助激光解吸电离飞行时间质谱技术(MALDI-TOFMS),检测283例冠心病患者与161例对照组人群MMP-2基因-1306C/T位点的基因型和等位基因的分布。结果:MMP-2基因-1306C/T位点基因型频率及等位基因频率在两组分布差异有统计学意义(P<0.01),经Logistic回归分析后,CC基因型携带者患冠心病风险是T等位基因携带者(CT+TT)的2.038倍(OR=2.038,95%CI=1.193-3.481,P<0.01)。结论:MMP-2基因-1306C/T位点与冠心病发病的危险性相关,CC基因型可能是冠心病发病的遗传危险因素。Objective To investigate the correlation between matrix metalloproteinase 2（MMP-2） gene-1306C/T polymorphism and coronary artery disease（CAD）.Methods Genotypes and allele distributions of MMP-2 gene-1306C/T in 283 patients with CAD and 161 controls were detected by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry（MALDI-TOF MS）.Results There were significant differences of genotypes and allele distributions of MMP-2 gene-1306C/T between the two groups（P 0.01）.Logistic regression analysis showed that the risk of CAD in patients with CC genotype was 2.038 folds of those with CT or TT genotypes（OR = 2.038,95% CI = 1.193-3.481,P 0.01）.Conclusion MMP-2 gene-1306C/T polymorphism is associated with the risk of CAD,the CC genotype may serve as a genetic risk factor for CAD.

关 键 词：冠心病 金属蛋白酶2 单核苷酸多态性 

分 类 号：R541.4[医药卫生—心血管疾病]