盐酸右美托咪定应用于蛛网膜下腔阻滞的临床观察  

Application of dexmedetomidine in spinal block

作　　者：王秀[1] 印春铭[1] 

机构地区：[1]中国医科大学附属四院麻醉科,沈阳市110032

出　　处：《实用医学杂志》2012年第10期1696-1697,共2页The Journal of Practical Medicine

摘　　要：目的:观察预防性静脉给予盐酸右美托咪定在蛛网膜下腔阻滞时的临床效果。方法:将患者随机分为两组,A组在蛛网膜下腔阻滞前给予盐酸右美托咪定0.5μg/kg(t=10min);B组静注氯化钠溶液2mL;观察两组不同时点的平均动脉压(MAP)、心率(HR)、感觉阻滞平面以及寒战发生率等其他不良反应。结果:在麻醉前(T1)、蛛网膜下腔阻滞后5min(T3)和手术完毕(T4)时点的MAP、HR组间比较差异无显著性(P>0.05),两组患者在给药后5min(T2)时点A组的MAP、HR低于B组,差异存在显著性(P<0.05);A组患者感觉阻滞平面(T5.1±0.8)高于B组(T6.0±0.9)(P<0.05);A组患者不良反应发生率降低(P<0.05),其中A组寒战发生率明显低于B组(P<0.05)。结论:手术中预防性静脉给予盐酸右美托咪定有良好的辅助蛛网膜下腔阻滞的作用。Objective To observe the efficacy of intravenous dexmedetomidine in spinal block. Methods All the patients were randomly divided into two groups：Group A received 0.5 μg/kg of dexmedetomidine before spinal block （n = 20）, Group B received 2 mL of NS （n = 20）. MAP, HR, the upper level of sensory block, and the incidence of shivering in the two groups were observed. Results There were no significant differences of HR and MAP before anesthesia （T1）, 5 minutes after spinal block （T3） and at the end of the operation （T4） between the two groups （P 〉 0.05）. HR and MAP in Group A was significantly lower than those in Group B 5 minutes after medication （T3） （P 〈 0.05）. The maximum upper level of sensory block in Group A （T5.1±0.8） were significantly higher than that in Group B （T6.0 ＋ 0.9） （P 〈 0.05）. The incidence of adverse effects （including shivering） in Group A was lower than that in Group B （P 〈 0.05）. Conclusion Venous injection of dexmedetomidiue before spinal block was an auxiliary effective method during operation.

关 键 词：麻醉药 局部 盐酸右美托咪定 寒战 

分 类 号：R614[医药卫生—麻醉学]