生长抑素阳性细胞与IgA阳性细胞在鸡十二指肠中的共存  

Coexistence of Somatostatin(SS)-Positive Cell and IgA-Positive Cell in Chicken Duodenum

作　　者：练高建[1,2] 杨倩[1] 

机构地区：[1]南京农业大学动物医学院,江苏南京210095 [2]南华大学实验动物学部,湖南衡阳421001

出　　处：《中国动物保健》2012年第5期15-17,共3页China Animal Health

基　　金：国家自然基金项目(30070564)

摘　　要：首次应用亲和免疫组化方法(ABC法)和免疫组化间接法(SPA-HRP间接法)同时显示了SS阳性细胞和IgA阳性细胞的在十二指肠中的分布情况。结果显示:SS阳性细胞主要分布于小肠绒毛上皮细胞之间、肠腺上皮细胞间及肠腺周围。IgA阳性细胞主要分布于小肠固有层中。在SS阳性细胞分布较多的部位,IgA阳性细胞的分布则较少;而在IgA阳性细胞分布较多的部位,SS阳性细胞则分布较少。提示SS对IgA细胞的合成有重要影响,说明SS对粘膜免疫有重要的调节作用。因此,通过半胱胺降低体内SS的水平来增加IgA阳性细胞的数量是一条行之有效的途径。The distribution of SS-positive cells and IgA-positive cells in chicken duodenum for the first time was labeled with double immunohistochemical staining. The results showed the SS-positive cells of the small intesti- nal mainly distributed around intestinal gland, within the epithelial cells of villus and intestinal gland.The I- gA-positive cells mainly distributed in the lamina propria of small intestinal.There will be many IgA-positive cells if there are few SS-positive cells,and vice versa.The results suggested SS played an important role in the synthesis of IgA. It demonstrated SS regulated the mucosal immunization. So it is an effective route to increase the number of IgA-positive cells by feeding cysteamine to decrease the level of SS.

关 键 词：生长抑素阳性细胞 IgA阳性细胞 鸡 十二指肠 共存 

分 类 号：S858.31[农业科学—临床兽医学]