血清、尿Cystatin C检测在糖尿病肾病中的临床应用价值陈红钟爱民  

Evaluation of serum and urine cystatin cin the early stage of type 2 diabetic nephropathy

作　　者：陈红[1] 钟爱民[1] 

机构地区：[1]江西省人民医院,南昌330006

出　　处：《江西医药》2012年第3期210-211,276,共3页Jiangxi Medical Journal

摘　　要：目的探讨血清、尿半胱氨酸蛋白酶抑制剂C(Cystatin C)在糖尿病肾病(DN)早期诊断中的价值。方法测定糖尿病正常蛋白尿组(A组),糖尿病微量蛋白尿组(B组),糖尿病大量蛋白尿组(C组)的血清、尿Cystatin C,尿α1微球蛋白(α1-MG),血清肌酐(SCR)和血尿素氮(BUN),比较各项指标。结果血Cystatin C值C组明显高于A、B组,B组高于A组,Cystatin C在3组之间差异均有统计学意义(P<0.05);BUN、SCR在A、B组中无显著性差异。各组间尿Cystatin C值的差异均有显著性(P<0.05)。患者尿的Cystatin C和α1微球蛋白的水平呈正相关(γ=0.81,P<0.01)。结论血清、尿Cystatin C分别是判断早期DN患者肾小球功能和肾小管受损的敏感指标。Objective To explore the value of serum and urine Cystatin C in the early stage of type 2 diabetic nephropathy.Methods 74 type 2 diabetic patients were divided into normal albumiuria group（A）,microalbumiuria group（B） and macroalbumiuria group（C） according to urine albumin excretion rate（UAE）.Serum and urine Cystatin C,α1-microglobulin（α1-MG）was determined by particle enhanced immunoturbidimetry.Serum creatinine（Scr）,and blood urea nitrogen（BUN） were detected simultaneously.Results Serum Cystatin C level of the group C was significantly higher than group B and A,the value was also different betweet group A and group B（P0.05）.but the value of BUN,Scr in the group A and B did not show differences.The value of urine Cystatin C and α1-MG show a high Correlation（γ=0.81,P0.01）.Conclusion Serum and urine Cystatin C is a sensitive marker to estimates glomerular filtration and tubular dysfunction of early diabetic nephropathy respectively.

关 键 词：糖尿病肾病 半胱氨酸蛋白酶抑制剂C Α1微球蛋白 

分 类 号：R587.2[医药卫生—内分泌]