新型5＇-脱氧核苷衍生物的合成  

Synthesis of Novel 5′-Deoxynucleoside Derivatives

作　　者：张逸伟[1] 刘子奇[1] 林东恩[1] 

机构地区：[1]华南理工大学化学与化工学院,广东广州510640

出　　处：《合成化学》2012年第3期349-351,共3页Chinese Journal of Synthetic Chemistry

摘　　要：以1,2,3-O-三乙酰基-5-脱氧核糖和6-氯嘌呤为主要原料,经Silyl反应制得6-氯-9-(2,3-二-O-乙酰基-5-脱氧-β-D-呋喃核糖)嘌呤(1);1经水解或与亲核试剂经取代和水解反应合成了5个未见文献报道的6-取代-5'-脱氧核苷衍生物,其结构经1H NMR和MS表征。Five novel 5-deoxy-/3-D-ribofuranosylpurine derivatives were synthesized by displacement and hydrolysis of 6-chloro-9- （2,3-di-O-acetyl-5-deoxy-β-D-ribofuranosyl） purine which was prepared by Silyl reaction of 1,2,3-tri-O-acetyl-5-deoxy-β-D-ribofuranose with 6-ehloropurine. The structures were characterized by 1H NMR and MS.

关 键 词：嘌呤 核糖 5'-脱氧核苷 合成 

分 类 号：O629.7[理学—有机化学]