可回收手性配体[QN(OH)_2]_2PHAL催化合成紫杉醇13-C侧链  

Synthesis of Taxol 13-C Side Chain Catalyzed by Recoverable Chiral Ligand

作　　者：南鹏娟[1] 赵海康[2] 陈晶[1] 崔新爱[1] 

机构地区：[1]陕西师范大学材料科学与工程学院,陕西西安710062 [2]西安医学院第二附属医院,陕西西安710038

出　　处：《合成化学》2012年第3期356-358,383,共4页Chinese Journal of Synthetic Chemistry

基　　金：国家自然科学基金资助项目(20973105)

摘　　要：在可回收手性配体[QN(OH)2]2PHAL的催化下,通过不对称氨羟化或双羟化反应合成紫杉醇13-C侧链,两种方法的产率分别为39%,97%ee和52%,99%ee,其结构经1H NMR,IR和元素分析确证。The taxol 13-C side chain was synthesized by asymmetric aminohydroxylation or dihydroxy- lation of trans-cinnamate using recoverable and resued chiral ligand [ QN （OH）2 ] 2PHAL as the catalyst. The structures were confirmed by 1H NMR, IR and elemental analysis. The yields were 39% with 97%ee and 52% with 99%ee, respectively by two methods.

关 键 词：不对称双羟化反应 不对称氨羟化反应 可回收手性配体 紫杉醇13-C侧链 合成 

分 类 号：O625.5[理学—有机化学] R914.5[理学—化学]