一种腙水解合成醛(酮)的绿色化学方法  

A Green Method for Synthesis of Carbonyl Compounds by Hydrolysis of Hydrazones

作　　者：全娜[1] 董菁[1] 吕霞[1] 聂良邓[1] 朱瑞恒[1] 施小新[1] 

机构地区：[1]华东理工大学药学院制药工程系,上海200237

出　　处：《合成化学》2012年第3期363-365,共3页Chinese Journal of Synthetic Chemistry

基　　金：国家自然科学基金资助项目(20972048);上海市教育发展基金资助项目(03SG27)

摘　　要：腙与二水合氯化铜在80%乙腈溶液中回流反应1 h～3 h,高收率地制得相应的醛(酮)。实现了铜盐的循环使用,符合绿色化学理念。Carbonyl compounds in high yields were synthesized by hydrolysis of hydrazones with cupric chloride dihydrate（ CuCl2 · 2H2O, 2 eq. ） in 80% acetonitrile aqueous under reflux. In addition, cupric salt was readily recovered in an almost quantitative yield via the complete precipitation of Cu（ OH）2, which could be reused for the above hydrolysis of hydrazones after being converted into CuCl2 · 2H2O.

关 键 词：腙 二水合氯化铜 水解 绿色化学 合成 

分 类 号：O625.6[理学—有机化学]