黄柏化学成分研究  

Chemical constituents from Phellodendron chinese

作　　者：李行诺[1] 翟文丰[1] 周孟宇[1] 沈培强 葛志伟[3] 颜继忠[1] 

机构地区：[1]浙江工业大学药学院,浙江杭州310032 [2]正大青春宝药业有限公司,浙江杭州310023 [3]浙江大学药学院,浙江杭州310058

出　　处：《浙江工业大学学报》2012年第3期244-246,共3页Journal of Zhejiang University of Technology

基　　金：国家重大科技专项项目(2009ZX09313-036)

摘　　要：对黄柏树皮Phellodendron chinese Schneid的化学成分进行研究,从中寻找有重要生物活性及药用前景的天然化合物.采用硅胶柱色谱法结合制备高效液相进行分离和纯化,根据理化性质和波谱数据进行结构鉴定.从黄柏树皮的乙醇提取物中分离得到6个化合物,分别为异阔果芸香碱(Ⅰ),γ-花椒碱(Ⅱ),茵芋碱(Ⅲ),铁屎米酮(Ⅳ),阿魏酸(Ⅳ),5-O-阿魏酰基奎宁酸(Ⅵ).化合物Ⅰ为首次从该属植物中分离得到.To search for bioactive natural products, the chemical constituents of Phellodendron chinese were studied. The compounds Ⅰ-Ⅵ were isolated by various chromatographic methods and their structures were identified by spectroscopic analysis. Six compounds were isolated from the ethanol etracts of Phellodendri chinensis Cortex. isoplatydesmine （Ⅰ）, γ-fagarine （Ⅱ）, skimmianine（ Ⅲ ）, canthin-6-one（Ⅳ ）, ferulic acid（ Ⅴ）, 5-O-feruloylquinic acids（ Ⅵ）. Compound Ⅰ was isolated from the Phellodendron genus for the first time.

关 键 词：黄柏 化学成分 生物碱 

分 类 号：R284.1[医药卫生—中药学]