丹参多酚酸盐治疗不稳定型心绞痛的疗效及其对AngⅡ、UA、VEGF的影响  

Curative effect of salvianolate on unstable angina and its influence on AngⅡ,UA and VEGF

作　　者：江宗朋[1] 季祥武[2] 张爱元[2] 张俊刚[2] 赵春华[2] 官宝礼[1] 

机构地区：[1]潍坊医学院,山东潍坊261053 [2]潍坊医学院附属潍坊市人民医院

出　　处：《山东医药》2012年第13期25-27,共3页Shandong Medical Journal

基　　金：国家自然科学基金资助项目(30873400)

摘　　要：目的研究丹参多酚酸盐治疗不稳定型心绞痛(UAP)的疗效及其对血液中血管紧张素Ⅱ(AngⅡ)、尿酸(UA)、血管内皮细胞生长因子A(VEGF-A)水平的影响。方法将60例UAP患者随机分为干预组和对照组各30例。对照组给予常规抗心绞痛治疗,干预组在对照组治疗的基础上加用丹参多酚酸盐注射液。比较两组临床疗效、血液中AngⅡ、UA、VEGF-A水平及心电图改善和药物不良反应情况。结果干预组临床疗效、血液中AngⅡ、UA水平及心电图改善情况均优于对照组(P<0.05)。两组均未发生严重药物不良反应。结论丹参多酚酸盐注射液治疗UAP安全、有效,并可降低血液中AngⅡ、UA水平,但对VEGF-A水平无显著影响。Objective To explore the clinical curative effect of salvianolate on patients with unstable angina pectoris （UAP） and its influence on the levesl of angiotensin- Ⅱ （ Ang Ⅱ ）, uric acid （UA） and vascular endothelial growth factor- A（VEGF-A） in blood. Methods Sixty cases were randomly divided into treatment group and control group, 30 cases of each. The control group was given conventional anti-angina treatment, while the intervention group based on the control group was added salvianolate injection. The clinical efficacy, levels of Ang 1I , UA, VEGF-A in blood, improvement situation of ECG, as well as the situation of adverse drug reaction（ADR） were observed. Results The clinical efficacy, levels of Ang Ⅱ , UA, as well as the improvement situation of ECG of the treatment group were respectively better than those of the control group （P 〈 0.05 ）. But the levels of VEGF-A in the blood before and after treatment were no significant difference （ P 〉 0.05 ）. Andserious ADR didn＇ t happen in the both groups. Conclusion Salvianolate can significantly ameliorate the symptoms and ECG ST-T segment of patients with UA, which can also significantly decrease the levels of Ang Ⅱ and UA. But it has no significant effect on the level of VEGF-A in the blood.

关 键 词：心绞痛 不稳定型 丹参多酚酸盐 血管紧张素Ⅱ 尿酸 内皮生长因子 

分 类 号：R541.4[医药卫生—心血管疾病]