慢性心力衰竭患者NT-ProBNP与hs-CRP检测的临床意义  

Clinical significance of serum Levels of Nt ProBNP and hs CRP among patients with Acute myocardial infarction and chronic heart failure

作　　者：问亚锋[1,2] 祁正军 陈健[2] 顾宗江[1] 

机构地区：[1]苏州大学医学生物技术研究所,215007 [2]江苏省淮安市楚州医院,223200

出　　处：《检验医学与临床》2012年第10期1210-1212,共3页Laboratory Medicine and Clinic

摘　　要：目的观察心力衰竭患者B型脑利钠肽前体(NT-ProBNP)、超敏C反应蛋白(hs-CRP)与心功能的相关性。方法测定70例慢性心力衰竭(CHF)患者(观察组)和68例健康体检者(对照组)血浆NT-ProBNP和血清hs-CRP水平。心脏彩色多普勒超声测定左室射血分数(LVEF)。比较两组NT-ProBNP、hs-CRP浓度变化与临床NYHA心功能分级、左室射血分数的情况。结果观察组hs-CRP水平和NT-ProBNP水平显著高于对照组,差异有统计学意义(P<0.01),且随着心功能分级的升高而升高,呈正相关(r=0.836,P<0.05)。随着LVEF值下降而升高,呈明显负相关(r=-0.724,P<0.05)。结论 NT-ProBNP、hs-CRP与CHF患者心功能状态有显著的相关性,可以作为诊断和病情检测、指导用药的客观指标。Objective To investigate the correlation of plasma level of pro brain natriuretic peptide（NT ProB- NP） and high sensitivity C reactive protein（hs-CRP） with the ardiac function of patients suffered with type chronic heart failure（CHF）. Methods The plasma level of NT ProBNP and hs CRP of 70 patients with CHF（treatment group） and 68 normal persons（control group） were tested. I.eft ventricular ejection fraction （LVEF） was determined in the two groups by ultrasound cardiogram. Then the level changes of NT ProBNP and hs CRP,the classification of cardiac function and LVEF were compared in the two groups. Results The plasma NT ProBNP and serum hs CRP levels in treatment group were significantly higher than that in controls（P〈 0.01）. There was a posotive correlation between plasma NT ProBNP and serum hs CRP with the degree of cardiac function（r= 0. 836, P〈 0.05）. Significantly negative relationships were also observed between plasma NT ProBNP and serum hs CRP levels with LVEF values（r=-0. 724,P〈 0. 05）. Conclusion The NT ProBNP and hs CRP levels have a good correlation with the cardiac function of patients with CHF,which may be the good objective indicators for the diagnosis of CHF, with guiding significance for medicine application.

关 键 词：慢性心力衰竭 B型脑利钠肽前体 超敏C反应蛋白 

分 类 号：R543.3[医药卫生—心血管疾病]