羟苯酯类防腐剂的不良反应  

Adverse Drug Reactions Induced by Parabens Used as Preservatives

作　　者：李中东[1] 张云轩[1] 郭燕萍[1] 施孝金[1] 钟明康[1] 

机构地区：[1]复旦大学附属华山医院药剂科,上海200040

出　　处：《中国药物警戒》2012年第5期303-305,共3页Chinese Journal of Pharmacovigilance

摘　　要：目的综述羟苯酯类防腐剂不良反应。方法参阅国外相关文献,总结羟苯酯类的不良反应。结果羟苯酯类是最常用的防腐剂,不良反应表现为过敏、交叉反应和激素效应,会发生"羟苯酯类悖论"现象。结论医务人员使用含羟苯酯类的制剂处方时,要重视它的不良反应,做到合理运用。Objective To review the adverse drug reactions induced by parabens when used as preservatives. Methods A simple conclusion on adverse drug reactions induced by parabens was carried out by reviewing the related references. Results Parabens are the most commonly used preservatives. Parabens are likely to cause adverse reactions as allergic reactions, cross reactions and estrogenic activity, paraben paradox can also be observed. Conclusion Professional clinicians must pay high attention to the adverse reactions of parabens contained in the pharmaceutical products and use them rationally as possible as they can.

关 键 词：羟苯酯类 过敏反应 交叉反应 羟苯酯类悖论 激素效应 

分 类 号：R943[医药卫生—药剂学] R994.11[医药卫生—药学]