醋狼毒炮制工艺研究  

Study on Preparation Processing Technique of Euphorbia ebracteolata Hayata

作　　者：汪兰云[1,2,3] 庄果[1,2,3] 张永鑫[1,2,3] 彭稳稳[1,2,3] 李俊松[1,2,3] 蔡宝昌 

机构地区：[1]南京中医药大学药学院,江苏南京210029 [2]南京中医药大学国家教育部中药炮制规范化及标准化工程研究中心,江苏南京210029 [3]南京海昌中药集团有限公司,江苏南京210061

出　　处：《南京中医药大学学报》2012年第3期265-268,共4页Journal of Nanjing University of Traditional Chinese Medicine

基　　金：国家公益性行业专项基金项目(200807039);南京中医药大学中药学一级学科开放课题(2011ZYX2-011)

摘　　要：目的确定醋狼毒饮片的最佳炮制工艺。方法以狼毒的毒性成分总二萜内酯,有效成分狼毒乙素、丙素及其灌胃给药后小鼠胃体PGE2含量作为确定最佳炮制工艺的考察指标,以醋的用量、炒制温度和炒制时间为影响因素,采用正交试验法L9(34)优选出了醋狼毒饮片的最佳炮制工艺。结果醋狼毒的优化炮制工艺,醋的用量为40%,炒制温度控制在160℃,炒制时间10min。结论优选出的醋狼毒炮制工艺可行,可值得推广应用。OBJECTIVE To establish the best processing technique of Euphorbia ebracteolata Hayata.METHODS The best processing technique was gained through determining the content of total lactones as the toxic components and determine the content of ebracteolata cpd B and ebracteolata cpd C as active ingredients and PGE2 contents of mice＇s digestive system after administration of euphorbia as index,and orthogonal design experiments L9（3^4） was used to investigate the factors of vinegar amount baked time and temperature.RESULTS The best processing technique was to add 40,vinegar and bake for 10 min at 160 ℃.CONCLUSION This best processing technique is stable,feasible and good repetition.

关 键 词：醋狼毒 炮制工艺 正交试验 

分 类 号：R283.3[医药卫生—中药学]