黄葵胶囊治疗原发性肾病综合征30例  

Clinical Study on Huangkui Capsules in Treatment of Primary Nephrotic Syndrome

作　　者：陈万欣[1] 胡晓燕 张志民[1] 唐静[1] 冯云生[1] 高洁[1] 

机构地区：[1]承德医学院附属医院,河北承德067000 [2]承德市双滦区人民医院内科,河北承德067000

出　　处：《南京中医药大学学报》2012年第3期289-291,共3页Journal of Nanjing University of Traditional Chinese Medicine

摘　　要：目的研究黄葵胶囊在原发性肾病综合征中的治疗作用。方法按纳入标准选择60例原发性肾病综合征患者,按随机数字表法随机分为试验组(30例)及对照组(30例),试验组应用黄葵胶囊加用泼尼松和/或环磷酰胺治疗,对照组单用泼尼松和/或环磷酰胺治疗。比较2组在总有效率、治疗指标(24h尿蛋白定量、血浆白蛋白、血脂、肾功能)及激素副作用等方面有无差异。结果 2组治疗后24h尿蛋白定量、胆固醇、甘油三酯含量均较治疗前明显降低,白蛋白含量较治疗前明显上升(P<0.05),试验组24h尿蛋白定量减少优于对照组,白蛋白含量升高更明显(P<0.05)。试验组总有效率绝对数值高于对照组,副作用发生率绝对数值低于对照组,但差异均无统计学意义(P>0.05)。2组肾功能均无明显变化。结论在治疗原发性肾病综合征中联合应用黄葵胶囊,疗效优于单用泼尼松和/或环磷酰胺治疗,并有降低激素副作用的趋势。OBJECTIVE To observe the effect of Huangkui Capsules in treatment of primary nephroticsyndrome.METHODS Sixty cases with primary nephrotic syndrome were randomly divided into two groups.The treated group（30 cases） were treated with Huangkui Capsules added prednisone and/or cyclophosphamide,and the controlled group（30 cases） were treated with prednisone and/or cyclophosphamide only.The total effective rate,the indexes and the side effect were compared in two groups.RESULTS The indexes of proteinuria in 24 hours,blood urea nitrogen（BUN）,blood lipid in two groups were lower compared with those before treatment.But it was better in the treated group（P〈0.05）.The total effective cases in the treated group was higher than those in the controlled group.The occuring cases of side effect in treated group was lower than patients in the controlled group（P〈0.05）.No significant difference was observed on the changes of the renal function in the two groups（P〈0.05）.CONCLUSION The therapeutic effect of Huangkui Capsules added prednisone and/or cyclophosphamide used to primary nephritic syndrome is superior to prednisone and/or cyclophosphamide used only;in addition,it shows a trend to reduced side effects of the prednisone.

关 键 词：原发性肾病综合征 黄葵胶囊 泼尼松 环磷酰胺 

分 类 号：R256.5[医药卫生—中医内科学]