HPLC法测定银杏内酯滴丸中银杏内酯A及银杏内酯B总量  

HPLC Determination of Ginkgolide A and Ginkgolide B Content in Ginkgolide Dropping Pills

作　　者：吴云[1] 颜丙鹏[1] 毕宇安[1] 仲艳[1] 萧伟[1] 

机构地区：[1]江苏康缘药业股份有限公司中药制药过程新技术国家重点实验室,连云港222001

出　　处：《世界科学技术-中医药现代化》2012年第2期1498-1501,共4页Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology

基　　金：科学技术部国家重大新药创制项目(2011ZX09401-097):中药治疗心脑血管疾病有效成份组(群)的创新药物孵化基地,负责人:萧伟

摘　　要：目的:建立银杏内酯滴丸中银杏内酯A、银杏内酯B含量测定方法。方法:采用高效液相色谱法,以正丙醇-四氢呋喃-水(1∶27∶72)为流动相,流速:1.0 mL.min-1,检测波长:220 nm。结果:建立了银杏内酯滴丸中银杏内酯A、银杏内酯B含量测定方法,且银杏内酯A、银杏内酯B的RSD分别为1.39%,2.16%。结论:本方法简便可靠,可用于银杏内酯滴丸的质量控制。This study was aimed to establish the ginkgolide dropping pills. High performance liquid THF-water （1：27：72） as the mobile phase. The flow The results showed that the determination method method of determining ginkgolide A and ginkgolide B content in chromatography （HPLC） was used in the research with N-propanol- rate was 1 mL-min-~. And the detection wavelength was at 220 nm. of ginkgolide A and ginkgolide B content in ginkgolide dropping pills was established. And the RSD of ginkgolide A and ginkgolide B were 1.39% and 2.16%, respectively. It was concluded that this method is simple and reliable, which can be used for quality control of ginkgolides dropping pills.

关 键 词：银杏内酯滴丸 银杏内酯A 银杏内酯B 

分 类 号：R285.5[医药卫生—中药学]