硒蛋白S基因多态性研究进展  

Progress of the study on genetic polymorphisms of selenoprotein S

作　　者：陈小丹[1,2] 张小爱[2] 吴志豪[3] 胡平成[1] 

机构地区：[1]中南大学公共卫生学院流行病与卫生统计学系,长沙410078 [2]军事医学科学院微生物流行病研究所病原微生物生物安全国家重点实验室,北京100071 [3]军事医学科学院疾病预防控制所,北京100071

出　　处：《生命科学》2012年第5期411-414,共4页Chinese Bulletin of Life Sciences

摘　　要：硒蛋白S(selenoprotein S,SELS)是一种在内质网和细胞膜潴留的硒蛋白,是一种新发现的炎症负调控因子,可以保护细胞免受氧化损伤,参与炎症和免疫反应。SELS基因多态性与肿瘤、心血管疾病、缺血性中风和先兆子痫等疾病的发生风险相关。简要介绍SELS的生物学功能,并对近年来SELS基因多态性与疾病易感性的研究进行回顾。Selenoprotein S （SELS） is a kind of selenoprotein located in the endoplasmic reticulum （ER） and the plasma membrane. It has been identified as a new negative regulator of inflammatory cytokine. It could protect ceils from oxidative damage, participate in the regulation of inflammatory and immunity response. Previous studies have shown that polymorphisms of SELS are associated with the risk of cancers, coronary heart disease, stroke, and preeclampsia. In this review, the biological role of SELS is discussed, and the recent advances of the SELS polymorphisms as well as their associations with the suscelptibility to many diseases are summarized.

关 键 词：硒蛋白S 基因多态性 遗传易感性 炎症 

分 类 号：O51[理学—低温物理] Q71[理学—物理]