不同中医治法对裸小鼠胰腺原位移植瘤的影响  

Effects on the Pancreatic Orthotopic Transplantation Tumor in Nude Mice by Different Chinese Medicine Therapeutic Methods

作　　者：张娟[1] 刘鲁明[1,2] 陈联誉[2] 王鹏[2] 花永强[2] 

机构地区：[1]上海中医药大学研究生院,上海201203 [2]复旦大学附属肿瘤医院中西医结合科,上海200032

出　　处：《中国中西医结合杂志》2012年第5期657-660,共4页Chinese Journal of Integrated Traditional and Western Medicine

基　　金：国家自然科学基金资助项目(No.81072942)

摘　　要：目的比较不同中医治法对裸小鼠胰腺原位移植瘤的影响,探讨胰腺原位移植瘤的中医治法特点。方法构建裸小鼠胰腺原位移植瘤模型。60只裸小鼠随机分为活血化瘀组、清热化湿组、健脾理气组、化痰散结组、正常对照1组和正常对照2组,每组10只。分别给予0.2mL对应中药汤剂或生理盐水灌胃,每天1次,共28天。观察各组体重、瘤重及抑瘤率。结果清热化湿组、活血化瘀组、健脾理气组、化痰散结组抑瘤率分别为42.69%、31.24%、2.11%、-12.95%。清热化湿组瘤重与正常对照1组比较,差异有统计学意义(g,0.51±0.28vs0.90±0.25,P<0.05),两组体重比较差异无统计学意义(P>0.05)。结论胰腺癌的中医病机有可能为湿热蕴结/湿热毒蕴,清热化湿法可能为胰腺癌治疗的基本大法。Objective To compare different Chinese medicine （CM） therapeutic methods on the pancre- atic orthotopic transplantation tumors in nude mice, and to explore their features. Methods The pancreatic orthotopic transplantation tumor model was established. Sixty nude mice were randomly divided into four group, i. e., the blood circulation activating and stasis resolving group, the heat clearing and dampness removing group, the Pi-strengthening and qi-regulating group, the phlegm reducing and mass resolving group, the normal control 1 group, and the normal control 2 group, 10 in each group. 0.2 mL corresponding CM decoction or normal saline was respectively administered to each group by gastrogavage, once dally, for totally 28 days. The body weight, the tumor weight, and the tumor inhibition ratio were observed. Results The tumor inhibition ratio was 42.69% in the heat clearing and dampness removing group, 31.24% in the blood circulation activating and stasis resolving group, 2.11% in the Pi-strengthening and qi-regulating group, and -12.95% in the phlegm reducing and mass resolving group. There was statistical difference in the tumor weight between the heat clearing and dampness removing group and the normal control 1 group （g,0.51 ±0.28 vs 0. 90 ±0.25, P 〈0.05）. There was no statistical difference in the body weight change between the two groups （ P 〉0. 05）. Conclusions The CM pathogenesis of pancreatic carcinoma may possibly due to the accumulation of dampness and heat, or the accumulation of dampness, heat, and toxicity. Clearing heat and removing dampness may be the basic principle for its treatment.

关 键 词：中医 证候 胰腺癌 

分 类 号：R273[医药卫生—中西医结合] R735.9[医药卫生—中医肿瘤科]