兔动脉粥样硬化易损斑块的磁共振成像特征  

MRI features of vulnerable plaques of atherosclerosis in rabbit models

作　　者：张明多[1] 马晓海[1] 曾聪贺[1] 冯婷婷[1] 张兆琪[2] 赵欣[1] 赵全明[1] 

机构地区：[1]首都医科大学附属北京安贞医院心内科18病房,北京100029 [2]首都医科大学附属北京安贞医院医学影像科,北京100029

出　　处：《中国医学影像技术》2012年第5期834-837,共4页Chinese Journal of Medical Imaging Technology

基　　金：国家自然科学基金(30972810、30870723)

摘　　要：目的探讨易损斑块与稳定斑块的MRI表现差异。方法选取20只雄性新西兰大白兔,以高脂饲料喂养加球囊拉伤主动脉的方法建立动脉粥样硬化模型。药物诱发斑块破裂前、后各进行1次MR扫描,之后处死动物,获得主动脉病理资料。对扫描所得数据与病理所见进行对比。结果 11只实验兔存活,MRI显示主动脉均呈不同程度的粥样硬化改变。其中7只成功诱发斑块破裂和血栓形成,共检出75个斑块,其中14个为易损斑块,61个为稳定斑块。MRI表现与病理学所见在纤维帽厚度、斑块面积、脂核面积方面相关度较高。与稳定斑块相比,易损斑块具有薄纤维帽、大脂核以及高脂核/斑块面积比等特点。脂核/斑块面积比是斑块易损性的较强预测因子。结论 MRI能够区分兔易损斑块和稳定斑块,可作为无创检测易损斑块的工具。Objective To explore the differences between vulnerable plaques and stable plaques in MRI.Methods Atherosclerosis was induced in 20 male New Zealand white rabbits by high cholesterol diet and balloon injury of the aorta.After baseline（pre-trigger） MR scan,the rabbits underwent 2 times of pharmaceutical triggering to induce atherothrombosis,followed by another MR scan（post-triggering）.The rabbits were euthanized to obtain pathological data.The results of MRI were compared with those of pathology.Results Eleven rabbits were alive after triggering.MRI showed that the aortas had pathological changes of atherosclerosis in different degrees.Thrombosis was identified in 7 of 11 rabbits by post-trigger MRI.Totally 75 plaques were detected,14 were vulnerable and 61 were stable.MRI data significantly correlated with histopathological findings in fibrotic cap thickness,plaque area and lipid core area.Compared with stable plaques,vulnerable plaques had thinner fibrotic cap,larger lipid core,and a higher ratio of lipid core area/plaque area.The ratio of lipid core area/plaque area was a strong predictor of vulnerable plaques.Conclusion MRI can distinguish vulnerable plaques from stable plaques in rabbit models of atherothrombosis,therefore might be used as an ideal noninvasive modality for the detection of vulnerable plaques.

关 键 词：血栓形成 磁共振成像 动物实验 兔 

分 类 号：R543.5[医药卫生—心血管疾病] R-332[医药卫生—内科学]