CD40/CD40L基因及其多态性与动脉粥样硬化的研究进展  

Developments in the study of CD40/CD40L gene and its polymorphism in atherosclerosis

作　　者：吴甜[1,2] 郭韧[1] 张毕奎[1,2] 

机构地区：[1]中南大学湘雅三医院药剂科 [2]中南大学药学院,长沙410013

出　　处：《中南大学学报（医学版）》2012年第4期413-418,共6页Journal of Central South University ：Medical Science

基　　金：国家自然科学基金(81000120)~~

摘　　要：CD40/CD40配体(CD40L)是一对互补的跨膜糖蛋白,表达于免疫细胞、内皮细胞、平滑肌细胞、血小板等多种细胞上,参与免疫、炎症、高凝等多种病理生理状态的调控。大量研究表明:当发生动脉粥样硬化时,CD40与CD40L结合活化后进入细胞,激活包括核转录因子NF-κB在内的下游信号通道,上调促炎和促血栓形成基因的表达,在动脉粥样硬化的发生发展以及斑块破裂诸多环节中发挥重要作用。CD40/CD40L是沟通免疫、炎症、高凝状态三者间的桥梁,可能是防治心血管疾病的重要靶点。CD40/CD40L is a pair of complementary transmembrane glycoproteins,expressed on immune cells,endothelial cells,smooth muscle cells,platelets and other cells involved in regulation of immunity,inflammation,coagulation and other pathophysiologic states.A large number of researches have demonstrated that,when atherosclerosis occurs,CD40L ligates CD40;subsequently CD40 is activated and stimulates downstream signaling pathways,including nuclear factor-kappaB,with consequent up-regulation of proin？ammatory and proatherogenic genes.Thus it plays an important role in the occurrence,development and plaque-rupture of atherosclerosis.CD40/CD40L is a bridge between immunity,inflammation,and a hypercoagulable state,and may be an important target for prevention and treatment of cardiovascular disease.

关 键 词：CD40/CD40L 动脉粥样硬化 单核苷酸多态性 疾病易感性 

分 类 号：R543.5[医药卫生—心血管疾病]