肝泡状棘球蚴病灶边缘移行带ADC值与纤维化面积相关性  

Correlation between apparent diffusion coefficient value and the area of fibrosis degree in border of hepatic alveolar echinococcosis

作　　者：谢卫东[1] 王静[1] 刘文亚[1] 任波[1] 肖虎[1] 

机构地区：[1]新疆医科大学第一附属医院影像中心,乌鲁木齐市830054

出　　处：《中华实用诊断与治疗杂志》2012年第5期467-469,共3页Journal of Chinese Practical Diagnosis and Therapy

基　　金：国家自然科学基金(30960100)

摘　　要：目的探讨表观弥散系数(apparent diffusion coefficient,ADC)评价肝泡状棘球蚴病(hepatic alveolarechinococcosis,HAE)病灶增殖活性的应用价值。方法 21例HAE患者均行肝脏MRI弥散加权成像扫描,获得弥散加权成像图像,对应病理取材部位测得病灶实质、边缘区域及周围肝脏组织ADC值,并进行比较;取其中14例患者的术后组织标本,对病灶边缘区域取材,行HE染色和MASSON染色,分析边缘移行带ADC值与镜下纤维化面积的相关性。结果 21例患者的病灶实质、病灶边缘区域和周围肝脏组织的ADC值比较差异有统计学意义(P<0.05);14例患者术后组织标本病灶边缘区域的ADC值与纤维化面积呈明显负相关(r=-0.767,P=0.001)。结论 HAE病灶边缘存在低ADC值的移行带;边缘带ADC值在一定程度上反映了病灶新近的空间结构和组织成分变化,可用于评价病灶浸润增殖活性。Objective To investigate the clinical value of apparent diffusion coefficient（ADC） to evaluating the development of hepatic alveolar echinococcosis（HAE）.Methods Twenty-one cases of HAE underwent GE 3.0 T Signal EXCITE MR-DWI.The MR-DWI ADCS of the center,the border and the around liver tissue of lesion were measured with liver DWI analysis software.Of these 21 cases of HAE,14 cases underwent operation.The slides of sample were stained with HE and MASSON to get fibrosis area.The correlation between MR-DWI ADC and fibrosis area was analyzed.Results There was a significant difference in the ADC among the center,border and the around liver tissues（P0.05）.The ADC in border of operation area was obviously negatively correlated with that in the area of fibrosis in 14 patients after operation（r=-0.767,P=0.001）.Conclusion There is transformation zone in the border of HAE with low ADC.The ADC can reflect the change of structure and composition,which can be used to evaluate HAE infiltration proliferative activity.

关 键 词：肝泡状棘球蚴 边缘带 MRI弥散加权成像 表观扩散系数 纤维化 

分 类 号：R532.32[医药卫生—内科学]