编织型复合管道支架的制备及载药性能  

Construction of a weaving tubular scaffold and its drug loading property

作　　者：张万灵 陈南梁[1,2] 赵炯心[3] 张秀芳[1] 王大新 

机构地区：[1]东华大学纺织学院,上海市201620 [2]产业用纺织品教育部工程研究中心,上海市201620 [3]东华大学材料学院,上海市201620 [4]扬州大学生物医学工程研究所,江苏省扬州市225009

出　　处：《中国组织工程研究》2012年第16期2905-2908,共4页Chinese Journal of Tissue Engineering Research

摘　　要：背景:金属材料和一般的高分子材料制备的管道支架生物相容性和载药性能很差,可降解高分子材料制备的管道支架具有很好的生物相容性,且双层复合结构有利于提高管道支架的径向支撑力和载药性能。目的:总结可降解高分子材料编织的双层复合管道支架的制作方法,探讨制作材料以及编织结构对管道支架的载药性能的影响。方法:用聚对二氧环己酮编织内层管道支架,用聚乙交酯丙交酯编织外层管道支架。以紫杉醇与阿奇霉素为药剂,测试管道支架载药后质量的变化。结果与结论:聚乙交酯丙交酯编织的单层管道支架的载药率大于聚对二氧环己酮编织的单层管道的载药率,聚乙交酯丙交酯与聚对二氧环己酮复合编织的双层管道支架的载药性能优于单层管道支架。BACKGROUND： Tubular scaffolds constructed using metal materials and general polymer materials have poor biocompatibility and drug loading property. Tubular scaffolds constructed using biodegradable polymer materials have good biocompatibility; besides, their double layer structure is good for the improvement of the radial support and drug loading property. OBJECTIVE： To expound a construction method of a weaving double-layer composite tubular scaffold using biodegradable polymer materials as well as to explore the effects of the manufacturing materials and weaving structure on the drug loading property of the tubular scaffold. METHODS： The lining tubular scaffold was weaved using poly （p-dioxanone）, while the outer tubular scaffold was weaved using poly （glycolide-co-lactide）. The change in quality of the tubular scaffold from before to after drug loading was detected using paclitaxel and azithromycin. RESULTS AND CONCLUSION： The drug loading rate of the single-storey tubular scaffold weaved using poly （glycolide-co-lactide） was higher than that of the single-storey tubular scaffold weaved using poly （p-dioxanone）. The drug loading rate of the two-storey composite tubular scaffold weaved using poly （glycolide-co-lactide） and poly （p-dioxanone） was superior to that of the single-storey tubular scaffold.

关 键 词：复合管道支架 可降解 编织 聚乙交酯丙交酯 载药性 

分 类 号：R318[医药卫生—生物医学工程]