增强磁共振评价大鼠部分脑组织切除模型术区周边组织形态的可行性  

Feasibility of contrast-enhanced magnetic resonance imaging in assessing the morphology of surrounding tissues around the surgical site in rat models of partial brain resection

作　　者：葛艳明[1] 李耀武[1] 徐敏[1] 孙西河[1] 张桂华[1] 辛顺宝[1] 刘凤杰[1] 董鹏[1] 

机构地区：[1]潍坊医学院附属医院影像中心,山东省潍坊市261031

出　　处：《中国组织工程研究》2012年第17期3152-3155,共4页Chinese Journal of Tissue Engineering Research

基　　金：山东省自然科学基金资助项目(ZR2010HM078)~~

摘　　要：背景:脑肿瘤手术切除后可以引起术区周边正常脑组织发生一系列改变,致使残存肿瘤的强化与正常脑组织的反应性强化在影像学上有时很难鉴别。目的:建立正常大鼠部分脑组织切除后模型,评价采用Micro23线圈对该模型行增强磁共振成像的可行性。方法:将18只成年SD大鼠随机分为术后3d组、术后7d组及正常对照组。术后3d组与术后7d组在无菌状态下切除部分正常脑组织,分别于术后3d和7d采用Micro23线圈行增强磁共振平扫及增强成像,正常对照组不做任何处理。结果与结论:术后3d组与术后7d组增强磁共振检查术区均清晰显示,术区周边脑组织反应性增强的发生率为100%。术后3d即出现强化,术后7d强化程度高于3d。增强的形式为环形、线形或斑片状,并对应于手术残腔的形状。说明采用Micro23线圈对部分正常脑组织切除模型大鼠行增强磁共振平扫及增强成像切实可行,术区周边脑组织的成像特点显示清晰。BACKGROUND：A series of pathological changes can occur in the normal brain tissues around the surgical site after brain tumor resection,leading to the difficult neuroimaging identification between the residual tumor-induced contrast enhancement and normal brain tissue enhancement.OBJECTIVE：To establish rat models of partial brain resection and to evaluate the feasibility of contrast-enhanced magnetic resonance imaging（MRI） in assessing the morphology of surrounding tissues around the surgical site by using Micro23 coil.METHODS：Eighteen rats were randomly divided into experimental group and control group.In the experimental group,a partial resection of the normal brain tissue was performed under aseptic conditions,and then,the rats were given contrast-enhanced MRI using Micro23 coil at 3 and 7 days postoperatively.There was no treatment in control group.RESULTS AND CONCLUSION：The contrast-enhanced MRI findings showed that the surgical margin was clear at 3 and 7 days postoperatively and the occurrence rate of contrast enhancement of the brain tissues around the surgical site was 100% in the experimental group.Contrast enhancement occurred at 3 days postoperatively and became higher at 7 days postoperatively.The shape of the surgical margin on contrast enhancement images was line-shaped or circular corresponding to the cavity.The findings suggested that contrast-enhanced MRI by using Micro23 coil was feasible for the experimental rat models of partial brain resection and it could display the imaging features of surgical margin clearly

关 键 词：增强磁共振成像 数字化医学 大鼠 脑 术后 

分 类 号：R318[医药卫生—生物医学工程]