2型糖尿病患者听力损失的相关因素研究  

Correlation Analysis of Hearing Loss in Patients with Type 2 Diabetes

作　　者：黄灿[1] 辛雅萍[1] 任健[2] 李真真[1] 张继佳[1] 张东铭[1] 王崇贤 付艳芹[1] 田晨光[1] 

机构地区：[1]郑州大学第二附属医院内分泌及代谢病科,郑州450014 [2]郑州市中心医院内分泌科

出　　处：《听力学及言语疾病杂志》2012年第3期217-220,共4页Journal of Audiology and Speech Pathology

基　　金：河南省卫生科技创新型人才工程专项经费(201004123)资助

摘　　要：目的探讨2型糖尿病患者听力损失的相关因素。方法对95例2型糖尿病患者(糖尿病组)及80例正常对照组进行纯音听力测试,同时对糖尿病组检测颈总动脉内径、颈动脉内膜中层厚度、颈部动脉粥样硬化斑块、空腹血胰岛素含量、纤维蛋白原、凝血酶原时间、血小板等7项可能的相关指标,分组比较及应用多自变量Lo-gistic回归分析探讨对听力的影响因素。结果糖尿病组听力异常者检出率为63.16%(60/95),对照组为40.0%(32/80);95例2型糖尿病患者中,听力正常组(35例)与听力减退组(60例)之间的颈总动脉内径、凝血酶原时间、血小板、颈动脉内膜中层厚度差异有统计学意义(P<0.05);42例颈部动脉无斑块者的语频及高频听力减退检出率分别为26.19%(11/42)、47.62%(20/42),而在53例颈部动脉有斑块的患者中分别为47.17%(25/53)、71.70%(38/53),均明显高于无斑块者(P<0.05),且高频听力减退更明显;Logistic回归分析显示,颈动脉内膜中层厚度、血小板、凝血酶原时间、空腹血胰岛素含量为2型糖尿病患者听力损失的相关因素。结论 2型糖尿病患者中有颈部动脉粥样硬化、高凝血倾向及高胰岛素水平者听力损失比例高。Objective To study the possible factors related to hearing loss in patients with type 2 diabetes. Methods Pure tone hearing test was carried out in 95 cases of type 2 diabete patients（diabete group） and 80 cases of normal control group.In the diabetic group,carotid artery diameter,carotid intima media thickness,carotid artery atherosclerotic plaques,fasting blood insulin levels,fibrinogen,prothrombin time and platelet 7 possible related indicators were measured,comparison botween the groups and multi-variable logistic regression analysis were applied. Results In diabete group,hearing loss detection rate was 63.16%（60/95）,while in control group,the detection rate was 40%（32/80）.The differences of inner diameter of the common carotid artery,prothrombin time,platelet,carotid intima-media thickness between the normal hearing group（35 cases） and hearing loss group（60 cases） in 95 cases patients of type 2 diabetes were statistically significant（P0.05）.In 42 cases patients without carotid artery plaque,speech frequency and high frequency hearing loss detection rates were 26.19%（11/42）,47.62%（20/42）respectively,while in 53 cases with carotid artery plaque,the rates were 47.17%（25/53）,71.70%（38/53） respectively,which were significantly higher than those of in non-plaque group（P0.05）.Logistic regression analysis showed that carotid intima-media thickness,platelet,prothrombin time,fasting blood insulin levels were relevant factors of hearing loss in type 2 diabetes patients. Conclusion Carotid artery atherosclerosis,high clotting tendency and high insulin levels in type 2 diabetes patients may be related to the a high incidence of hearing loss in type 2 diabetes paitents.

关 键 词：2型糖尿病 听力损失 相关因素 

分 类 号：R764.5[医药卫生—耳鼻咽喉科]