6-芳甲氧基-7-甲基-4-羟基-3-喹啉羧酸乙酯类化合物的合成及抗球虫活性研究  

Synthesis and anticoccidial activities of ethyl 6-arylmethoxy-7-methyl-4-hydroxy-3-quinolinecarboxylates

作　　者：严春蓉[1,2] 徐慧远[2] 罗娟[1] 王玉良[1] 

机构地区：[1]四川大学化学学院,四川成都610064 [2]宜宾学院化学与化工学院,四川宜宾644000

出　　处：《化学研究与应用》2012年第5期796-800,共5页Chemical Research and Application

基　　金：国家自然科学基金项目(Nos.21072135)资助

摘　　要：本文通过亚硝化、催化氢化、EMME缩合、醚化和关环五步反应合成了3个未见文献报道的6-芳甲氧基-7-甲基-4-羟基-3-喹啉羧酸乙酯类化合物。所有化合物的结构均经1H NMR,IR和HRMS等方法确证。对三个化合物进行了抗球虫活性实验,实验结果表明,在27 mg/kg的使用浓度下,化合物6-苄氧基-7-甲基-4-羟基-3-喹啉羧酸乙酯(5a)具有抗球虫活性。Three ethyl 6-arylmethoxy-7-methyl-4-hydroxy-3-quinolinecarboxylates compounds were synthesized through five step reactions of nitrification, catalytic hydrogenation, condensation, etherification and closed loop response. The structures of these com- pounds were confirmed by 1H NMR, IR spectra and HRMS. Anticoccidial activities of these compounds were evaluated according to the anticoccidial index method. The result indicated that ethyl 6-benzyloxy-7-methyl-4-hydroxy-3-quinolinecarboxylate（Sa）had anticoecidial activity against Eimeria in chicken＇ s diet with a dose of 27 mg/kg.

关 键 词：6-芳甲氧基-7-甲基-4-羟基-3-喹啉羧酸乙酯 合成 抗球虫活性 

分 类 号：O626.323[理学—有机化学]