淫羊藿女贞子合用地塞米松抗哮喘大鼠的研究  

Experimental study on effect of combination of Epimedii Folium/Ligustri Lucidi Fructus and dexamethasone on asthmatic rats

作　　者：刘仁慧[1] 许利平[1] 王秀娟[1] 杨婧[1] 王培[1] 潘凉[1] 

机构地区：[1]首都医科大学中医药学院,北京100069

出　　处：《中国中药杂志》2012年第10期1497-1499,共3页China Journal of Chinese Materia Medica

基　　金：国家自然科学基金项目(30801494);北京市优秀人才项目(20081D0501800209);北京市中医药薪火传承"3+3"工程二室一站项目

摘　　要：目的:研究地塞米松合用淫羊藿女贞子治疗哮喘的协同抗炎作用及对激素不良反应的改善作用。方法:给予哮喘大鼠模型腹腔注射地塞米松2周,同时配合灌胃淫羊藿女贞子,观察支气管肺泡灌洗液(BALF)IL-4,INF-γ,IL-5含量;血清COR,血浆ACTH,下丘脑CRH含量;BALF中GCR蛋白表达。结果:淫羊藿女贞子合用地塞米松能显著下调哮喘模型大鼠BALF中IL-5,IL-4含量,上调IFN-γ表达,调节Th1/Th2失衡;降低血浆ACTH,CRH含量;上调BALF中GCR的蛋白含量及结合力。结论:淫羊藿合用地塞米松可以增强激素的抗炎作用,并对内源性糖皮质激素作用途径起到保护作用。Objective： To study the anti-inflammatory effect of the combination of Epimedii Folium, Ligustri Lucidi Fructus and dexamethasone on asthma and its effect in inhibiting adverse reaction against hormone. Method： Dexamethasone had been injected intraperitoneally into asthmatic model rats for 2 weeks, together with the oral administration of Epimedii Folium and Ligustri Lucidi Fructus. The contents of IL-4, INF-γ, IL-5 and GCR in BALF, serum COR, plasma ACTH and hypothalamic CRH were observed. Result： The combination of Epimedii Folium, Ligustri Lucidi Fructus and dexamethasone can significantly decrease the contents of IL- 5 and IL-4 in BALF and ACTH and CRH content in plasma, increase the content of IFN-γ and GCR in BALF and balance Th1/Th2. Conclusion： The combination of Epimedii Folium, Ligustri Lucidi Fructus and dexamethasone has a better anti-inflammatory effect on asthmatic model rats, and play a protective role in the pathway of endogenous dexamethasone.

关 键 词：哮喘 糖皮质激素 淫羊藿/女贞子 抗炎 下丘脑-垂体-肾上腺轴 

分 类 号：R562.25[医药卫生—呼吸系统]