血管紧张素Ⅱ受体AT1拮抗剂治疗原发性高血压的临床疗效及其对血清脂联素水平的影响  

Clinical effects of angiotensinⅡ and AT1 receptor antagonist in patients with essential hypertension and its effects on serum adiponectin

作　　者：王可[1] 

机构地区：[1]河南科技大学第一附属医院心血管内科,河南洛阳471000

出　　处：《现代预防医学》2012年第10期2602-2603,2605,共3页Modern Preventive Medicine

摘　　要：目的探讨血管紧张素Ⅱ受体AT1拮抗剂治疗原发性高血压的临床疗效及对血清脂联素水平的影响。方法 70例原发性高血压患者(观察组)给予血管紧张素Ⅱ受体AT1拮抗剂(缬沙坦)治疗,连续治疗30d后评价疗效,并选择30例健康者为对照组,测定观察组和对照组血清脂联素水平。结果观察组治疗后,临床疗效总有效率为97.1%;观察组治疗后血压明显改善,SBP、DBP水平与治疗前比较差异有统计学意义(t=3.782,3.723,P﹤0.05),血清ADP水平显著上升,与治疗前比较差异有统计学意义(t=4.891,P﹤0.05)。治疗前观察组SBP、DBP水平显著高于对照组,两组相比较差异有统计学意义(t=3.897,3.782;P﹤0.05);ADP水平显著低于对照组,两组相比较差异有统计学意义(t=5.330;P﹤0.05)。结论血管紧张素Ⅱ受体AT1拮抗剂能有效降压和升高原发性高血压患者血清ADP水平,是治疗原发性高血压有效方法,值得临床推广应用。OBJECTIVE To investigate the clinical effects of angiotensinⅡand AT1 receptor antagonist in patients with essential hypertension and its effects on serum adiponectin.METHODS 70 cases of patients with essential hypertension（observation group）were treated with angiotensinⅡand AT1 receptor antagonist（valsartan）.After 30 days of continuous therapy,the clinical effects was evaluated,and 30 healthy were selected as the control group.The serum adiponectin levels of two groups was detected.RESULTS After treatment,the total effective rate of the observation group was 97.1%.After treatment,the blood pressure of the observation group was significantly improved.The SBP and DBP levels showed significantly difference compared with those before treatment（t = 3.782,3.723,P﹤0.05）.The serum ADP levels were significantly increased,and showed significant difference compared with the control group（t = 4.891,P﹤0.05）.The SBP and DBP levels of the observation group in the pre-treatment was significantly higher than those of the control group（t = 3.897,3.782,P﹤0.05）;The ADP levels was significantly lower than that of the control group（t = 5.330,P﹤0.05）.CONCLUSION The angiotensinⅡand AT1 receptor antagonist can effectively improve blood pressure and elevate serum ADP levels.This method is an effective way in treatment of essential hypertension,and is worthy of clinical application.

关 键 词：血管紧张素Ⅱ受体AT1拮抗剂 脂联素 降压 原发性高血压 

分 类 号：R544.1[医药卫生—心血管疾病]