国产重组人生长激素治疗特发性生长激素缺乏症的疗效  

THE EFFICACY OF DOMESTIC RECOMBINANT HUMAN GROWTH HORMONE IN TREATMENT OF IDIOPATHIC GROWTH DEFICIENCY CHILDREN

作　　者：覃舒文[1] 史轶蘩[1] 沈水仙 林丽香[3] 谢永明[1] 邓洁英[1] 刘希红 李红 陈萱林[3] 吴红[3] 吴勤勇[1] 张殿喜[1] 

机构地区：[1]中国医学科学院中国协和医科大学北京协和医院,北京100730 [2]上海儿科医院内分泌科,上海200032 [3]福建省立医院内分泌科,福州350001

出　　处：《中国新药杂志》2000年第5期323-325,共3页Chinese Journal of New Drugs

摘　　要：目的 :评价国产重组人生长激素 (Met rhGH)治疗特发性生长激素缺乏症 (IGHD)的疗效和安全性。方法 :对 6 3例IGHD以Met rhGH进行治疗 ,每晚临睡前皮下注射 0 .12IU/ (kg·d)共 6个月。结果 :6 3例患者身高平均增加 ( 6 .8± 1.7)cm ,年生长速度由治疗前的 ( 2 .5± 1.1)cm/年增加到 ( 11.6± 3.3)cm/年 ,身高标准差计分 (SDS)由治疗前的 ( - 4.6± 1.5 )变为 ( - 3 .8± 1.6 ) ;但体重和骨龄无明显变化。治疗前后共有 38.1%的患者出现亚临床甲状腺功能低减 ,30 .9%的患者于注射局部出现短暂的红肿或痒等 ,93 .7%的患者血清出现低滴度的抗rhGH抗体 ,但所有这些现象均未影响患者体格的线性增长。结论 :国产Met rhGH是治疗IGHD的安全。OBJECTIVE: To assess the efficacy of recombinant growth hormone with one more methionine (MetrhGH) in treatment of idiopathic growth hormone deficiency (IGHD) children. METHODS: 63 children with IGHD were treated with MetrhGH in a daily dose of 0.12IU/kg given by sc injection before sleep for 6 months. RESULTS: The mean height, mean growth velocity, and mean height SDS increased from (119.6±13.7)cm,(2.5±1.1)cm/year, and (-4.6±1.5)to (125.4±13.0)cm, (11.6±3.3)cm/year, and (-3.8±1.6) respectively (all of these P<0.05). No advanced bone maturation and weight gain. During the course of therapy, there were 38.1%, 30.9% , and 93.7% patients suffered from subclinical hypothyroidism, local reaction in injection sites, increment of low titer serum antirhGH antibody respectively. All of these phenomena had no effect on their linear body growth. CONCLUSION: This domestic MetrhGH is an effective and safe agent for promoting growth in children with IGHD.

关 键 词：特发性生长激素缺乏症 重组人生长激素 药理 

分 类 号：R584.205[医药卫生—内分泌] R977.1[医药卫生—内科学]