左卡尼汀对新兵越野跑后血清葡萄糖和游离脂肪酸的影响  

EFFECTS OF L-CARNITINE ON SERUM GLUCOSE AND FREE FATTY ACID OF MILITARY RECRUITS AFTER 5KM CROSS-COUNTRY RUNNING

作　　者：陈景开 宗刚军 余明[2] 陈满清 赵秋良 夏阳 吴刚勇 张维维 

机构地区：[1]解放军第一○一医院心内科 [2]73036部队卫生队

出　　处：《解放军预防医学杂志》2012年第2期99-102,共4页Journal of Preventive Medicine of Chinese People's Liberation Army

摘　　要：目的观察左卡尼汀对新兵空腹5000 m越野跑前后血清葡萄糖(Glu)和游离脂肪酸(FFA)的影响,为探讨军训低血糖的预防方法提供依据。方法选入伍男性新兵54名,随机分为服药组(n=24)和对照组(n=30)。服药组于空腹越野跑5000 m前10 d开始口服左卡尼汀,1.0g,3次/d;对照组服安慰剂。检测跑前10 min与跑后即刻和4 h时Glu、糖原磷酸化酶同功酶BB(Glycogen phosphorylase isoenzyme BB,GPBB)、FFA和心型脂肪酸结合蛋白(heart-type fatty acid-bind-ing protein,H-FABP)的变化,并与对照组比较。结果服药组越野跑前10 min Glu为(4.65±0.32)mmol/L,越野跑后的即刻为(5.66±1.02)mmol/L,越野跑后4 h为(4.49±0.66)mmol/L,显著高于对照组〔(3.78±0.52)mmol/L(、4.36±0.48)mmol/L、(3.89±0.46)mmol/L〕(P<0.01)。服药组在越野跑后4 h,FFA为(126.27±56.77)μmol/L,显著高于对照组〔(99.78±18.76)μmol/L〕(P<0.01)。服药组越野跑后H-FABP无显著变化(P>0.05);2个组在越野跑后4 h,GPBB虽显著高于越野跑前10 min(P<0.01),但服药组在越野跑后即刻和4 h均显著低于对照组(P<0.01)。结论左卡尼汀可提高越野跑前后Glu水平,减少越野跑后FFA的下降,对预防新兵空腹越野跑所致的低血糖具有一定的保护作用。Objective To evaluate the effect of L-carnitine on serum glucose and free fatty acid in military recruits during 5 km cross-country running,so as to provide the basis for preventing hypoglycemia during military training,Methods Fifty-four recuits were divided into treatment group（n=24,took L-carnitine 1.0 g tid for 10 days） and control group（n=30,took placebo）.Then the subjects performed a 5 km cross-country running on an empty stomach.Blood was taken for meauring glucose,free fatty acid,glycogen phosphorylase isoenzyme BB（GPBB）,and heart-type fatty acid-binding protein（H-FABP）before and after exercise.Results The levels of serum glucose in treatment group（（4.65 ± 0.32）mmol/L 10 minutes before exercise,（5.66±1.02）mmol/L post-exercise immediately,and（4.49±0.66）mmol/L 4 h after exercise） were higher than in control group（（3.78±0.52）mmol/L,（4.36±0.48）mmol/L,and（3.78±0.52）mmol/L respectively）（P0.01）.The free fatty acid in treatment group（（126.27±56.77）mmol/L）was higher than in control group（（99.78±18.76）mmol/L）（P0.01） 4 h after exercise.Although increase in the level of GPBB was found in treatment group 4 h after exercise（P0.01）,it was lower than that in control group（P0.01）.Conclusion Carnitine may raise up the level of serum glucose and relieve the fall of serum free fatty acid after exercise in recruits,and is advantageous to preventing hypoglycemia from exercise on an empty stomach.

关 键 词：新兵 越野跑 左卡尼汀 血糖 游离脂肪酸 糖原磷酸化酶同功酶BB(GPBB) 心型脂肪酸结合蛋白(HFABP) 

分 类 号：R587.1[医药卫生—内分泌] Q574[医药卫生—内科学]