褪黑激素对大鼠基础痛阈的影响  

INFLUENCE OF MELATONIN ON BASIC PAIN THRESHOLD IN RATS

作　　者：周裔春 邱学才[2] 

机构地区：[1]九江医学专科学校生理教研室,九江332000 [2]北京医科大学生理系,北京100083

出　　处：《中国药物依赖性杂志》2000年第2期104-105,共2页Chinese Journal of Drug Dependence

基　　金：天然药物仿生药物国家重点实验室资助

摘　　要：观察增加外源性和内源性褪黑激素 (MT)对大鼠基础痛阈的影响。方法··:用热辐射甩尾法测定腹腔注射不同剂量的MT及切除颈交感神经节对大鼠的基础痛阈的影响。结果··:腹腔注射不同剂量的MT可提高大鼠的基础痛阈 ,并呈量效关系。其镇痛作用可被纳洛酮部分阻断。切断抑制松果腺分泌的颈交感神经节后 ,也可提高大鼠的基础痛阈。结论··:外源性和内源性MT均具有镇痛作用。纳洛酮可部分翻转MT的镇痛效应。Objective: To observe the influence of exogenous melatonin (MT)and endogenous MT on pain threshold in rats. Method: The tail flick latency was taken to represent the pain threshold which was measured after intraperitoneal injection (ip) of different doses of MT and cervical sympathetic ganglionectomy. Result: The pain threshold may be dose-dependently increased by ip different doses of MT and attenuated by naloxone. The pain threshold may also be increased by cervical sympathetic ganglionectomy. Conclusion: Both exogenous MT and endogenous MT possess analgesic effects.The analgesic effect of MT can be attenuated by naloxone.

关 键 词：褪黑激素 颈交感神经节 镇痛 

分 类 号：R335.9[医药卫生—人体生理学] R339.11[医药卫生—基础医学]