海洛因依赖者T细胞亚群变化及人参四物汤作用研究  

REGULATIVE EFFECT OF GINSENG SIWU DECOCTION ON T CELL SUBSETS IN HEROIN ADDICTS

作　　者：刘屏[1] 宋森林[2] 李宾[1] 崔宝庆 陈世铭[1] 

机构地区：[1]解放军总医院临床药理研究室,北京100853 [2]北京瑞达医院,北京100040

出　　处：《中国药物依赖性杂志》2000年第2期115-117,共3页Chinese Journal of Drug Dependence

基　　金：国家中医药管理局科研基金!(95B155)

摘　　要：研究长期摄入吗啡对机体主要的免疫调控细胞Th、Ts亚群的影响和中药人参四物汤的调节作用。方法·· :流式细胞仪测定各组海洛因依赖者外周血Th、Ts亚群数目。结果··:烫吸海洛因依赖者的Th、Ts亚群数明显低于健康人群 ,服用人参四物汤组的患者 ,T细胞亚群数目有所增加 ,静脉注射海洛因依赖者的Th/Ts倒置。结论·· :海洛因依赖者的免疫功能有明显损伤 ,iv较之烫吸对T细胞损伤更甚 ,人参四物汤可缓解海洛因依赖者的免疫损伤作用。Objective: To investigate the change of T cell subsets (Th, Ts cells)and the regulative effect of Ginseng Siwu decoction, a traditional Chinese medicine, in 42 cases of heroin addicts. Method: The number of Th,Ts cells was assayed by FACS in heroin addicts before and after detoxification therapy. Result: The number of Th, Ts cells in snorting heroin addicts decreased compared with those of control and Ginseng Siwu group , however, the number of Th cells reduced and Ts cells increased in intravenous heroin addicts . Conclusion: Heroin dependence did obvious damage to the immunofunction of heroin addicts, and the damage of T cells in intravenous heroin addicts was more serious than that in snorting heroin addicts. Ginseng Siwu decoction was able to minimize this damage.

关 键 词：T细胞亚群 人参四物汤 海洛因依赖 

分 类 号：R595.5[医药卫生—内科学]