二维超声斑点追踪技术对兔室壁瘤形成后左心室扭转角度的研究  

Assessment of left ventricular twist in rabbits with ventricular aneurysm formed by two-dimensional speckle tracking echocardiography

作　　者：闫雪[1] 关丽娜[1] 穆玉明[1] 翟虹[1] 周玉成[1] 

机构地区：[1]新疆医科大学第一附属医院超声医学中心心脏超声诊断科,乌鲁木齐830011

出　　处：《中华超声影像学杂志》2012年第5期435-438,共4页Chinese Journal of Ultrasonography

基　　金：新疆医科大学科研专项基金（2011YFY07）

摘　　要：目的应用二维超声斑点追踪技术（STI）评价兔心肌梗死后室壁瘤形成对左室扭转角度的影响及其与心功能的关系。方法26只健康新西兰大白兔，6只作为对照组，20只作为实验组，结扎左前降支及左回旋支制作心肌梗死模型和室壁瘤模型，饲养4周后，根据病理学检查有无室壁瘤形成将实验组分为心肌梗死组和室壁瘤组，应用STI分别测量各组左室短轴瓣环水平、心尖水平各节段的旋转角度及左室整体扭转角度，并进行左室腔大小及心功能的检测。结果室壁瘤组左室舒张末期内径（LVEDD）、舒张末期容积（LVEDV）均较心肌梗死组增大，左室射血分数（LVEF）、左室短轴缩短率（LVFS）、左室短轴心尖水平旋转角度及左室整体扭转角度均较心肌梗死组减小。心尖水平旋转角度、左室整体扭转角度与左室射血分数相关性良好。ROC曲线分析显示，心尖水平旋转角度为1．21。时，判断LVEF〈50％的灵敏性为76．9%，特异性为80．0％。结论心尖部旋转角度的变化与左室收缩功能密切相关，当心尖水平旋转角度下降至1．21。时可提示左室收缩功能明显下降。Objective To evaluate the influence on left ventrieular（LV） twist,and the relationship between LV twist and function in the rabbits with ventricular aneurysm formed after myocardial infarction by two-dimensional ultrasound speckle tracking imaging. Methods Twenty-six healthy rabbits were divided into two groups, six as control group, twenty as experimental group. The model of myocardial infarction and ventricular aneurysm were established by ligaturing left anterior descending coronary artery and left circumflex artery. After four weeks, according to the pathological examination of whether ventricular aneurysm formed or not,the experimental group was divided into myocardial infarct group and ventricular aneurysm group. Echocardiography was performed to measure rotations （at the levels of mitral annulus and apex in LV short-axis view） ,LV twist,left ventricular cavity size and function. Results Compared with the myocardial infarct group,LV end-diastolic diameter（LVEDD） and LV end-diastolic volume（LVEDV） were larger in the ventricular aneurysm group, but LV ejection fraction （LVEF）, LV fractional shortening （LVFS） ,apical rotation and LV twist were lower in the ventricular aneurysm group than the myocardial infarct group. Both apical rotation and LV twist had shown a great correlation with LVEF. The conclusion was also shown in the ROC curve that sensitivity and specificity of diagnosis cardiac dysfunction were 76. 9% and 80.0% respectively when the apical rotation was 1.21°. Conclusions There was a closely relationship between the change of apical rotation and the LV systolic function. When the apical rotation dropped to 1.21°, an apparent decline of LV systolic function was implied.

关 键 词：超声心动描记术 心脏室壁瘤 心室功能 左 旋转 斑点追踪显像 

分 类 号：R542.22[医药卫生—心血管疾病]