他达拉非对中老年男性LOH患者T、IIEF及SEP影响的临床研究  

Tadalafil improves total testosterone,IIEF score and SEP in old and middle-aged males with late-onset hypogonadism

作　　者：王玺坤[1] 罗力[1] 王森[1] 李峻[1] 李文雄[1] 

机构地区：[1]广东药学院附属第一医院泌尿外科,广东广州510080

出　　处：《中华男科学杂志》2012年第5期475-477,共3页National Journal of Andrology

摘　　要：目的:观察他达拉非联合安特尔治疗中老年男性迟发性性腺功能低下(LOH)的临床疗效。方法:选择125例中老年男性LOH患者随机分为两组,治疗组65例使用他达拉非加十一酸睾酮治疗,对照组60例使用十一酸睾酮胶囊治疗。分别记录治疗前及治疗后4周时的总睾酮(T)、国际勃起功能指数评分(IIEF)、患者性生活日记(SEP)等的变化。结果:治疗后2组T、IIEF及SEP评分均有不同程度改善,与治疗前比较,差异均有统计学意义(P<0.05);治疗组T、IIEF及SEP评分改善更为显著,与对照组比较,差异均有统计学意义(P<0.05)。结论:使用他达拉非联合十一酸睾酮胶囊,可较好地改善中老年男性患者T、IIEF及SEP分数,提高患者性生活满意度及自信心,具有比单纯补充睾酮更好的综合疗效。Objective： To observe the clinical effect of tadalafil combined with testosterone undecanoate on late-onset hypogonadism（LOH） in old and middle-aged males.Methods： A total of 125 old and middle-aged（40 to 60 years） males with LOH were randomly assigned to a treatment group（n = 65） and a control group（n = 60） to be treated with tadalafil ＋ testosterone undecanoate and testosterone undecanoate alone,respectively.We compared the levels of total testosterone（T）,IIEF scores and the patients＇ sexual encounter profile（SEP） diaries before and 4 weeks after medication.Results：The T level,IIEF score and SEP score were significantly improved in both groups after medication as compared with the baseline（P 0.05）,and even more so in the treatment than in the control group（P 0.05）.Conclusion： Tadalafil combined with testosterone undecanoate,superior to testosterone undecanoate alone,can improve the T level,IIEF score and SEP score in old and middle-aged males with LOH and increase their sexual satisfaction and self-confidence.

关 键 词：他达拉非 迟发性性腺功能低下 勃起功能障碍 

分 类 号：R698.1[医药卫生—泌尿科学]