泡沫逆转录病毒Bet蛋白的研究进展  

The Research Progress of Foamy Virus Bet Protein

作　　者：高原[1] 孙燕[1] 李治[1] 刘清梅[1] 刘万红[2] 何小华[2] 

机构地区：[1]陕西师范大学生命科学学院,西安710062 [2]武汉大学基础医学院,武汉430071

出　　处：《病毒学报》2012年第3期285-290,共6页Chinese Journal of Virology

基　　金：国家自然科学基金(编号:31170154;31000086;30970145和30870856);教育部科学技术研究重点项目(108184)

摘　　要：泡沫逆转录病毒能长期感染哺乳动物宿主而不引发疾病,这一特点引起研究者们极大兴趣。有研究发现,泡沫逆转录病毒的辅助蛋白Bet不仅能调控病毒的基因表达和感染周期,对病毒慢性感染的建立有重要作用;还能阻止宿主细胞防御因子APOBEC3对病毒复制产生干扰,与病毒持续性感染的维持有关。为了阐明Bet在病毒复制和感染时所发挥的作用,本文对近年来有关Bet蛋白功能的研究进行了分析和总结。Foamy virus can establish lifelong persistent infection in mammal hosts without inducing disea- ses. Such special characteristic stimulates the interests of researchers. As reported, the accessory protein Bet of foamy virus could regulate the gene expression and infection cycle of foamy virus and take part in the generation of chronic viral infection. And also, Bet might prevent the host cellular defense factor APO- BEC3 from interfering the replication of virus and play a role in maintaining viral persistent infection. In order to elucidate the roles of Bet in the foamy virus replication and infection, this review summarized the research progress of Bet protein reported in recent years.

关 键 词：泡沫逆转录病毒 辅助蛋白 基因表达 感染周期 细胞防御因子 

分 类 号：R373.9[医药卫生—病原生物学]