广东虫草对腺嘌呤诱导的慢性肾衰竭大鼠的治疗作用(英文)  

Therapeutic effects of Cordyceps guangdongensis on chronic renal failure rats induced by adenine

作　　者：闫文娟[1,2] 李泰辉[1] 姜子德[2] 

机构地区：[1]广东省微生物研究所、广东省菌种保藏与应用重点实验室、广东省微生物应用新技术公共实验室、广东省华南应用微生物重点实验室-省部共建国家重点实验室培育基地,广东广州510070 [2]华南农业大学资源环境学院,广东广州510642

出　　处：《菌物学报》2012年第3期432-442,共11页Mycosystema

基　　金：广东省自然科学基金(Nos.10151007002000006,E05202480);广东省科技计划项目(Nos.2009B080702029,2010A030100015);广东省产学研项目(No.2011B090400625)

摘　　要：广东虫草Cordyceps guangdongensis是广东省微生物研究所近年发现并成功驯化的独有新品种,前期研究发现其具有抗氧化、抗疲劳、延缓衰老等药理作用,但其对慢性肾衰竭的治疗作用还未见报道。实验采用饲喂腺嘌呤诱导大鼠慢性肾衰竭(CRF)模型,观察比较了阴性对照组、阳性对照组、广东虫草子实体低、中、高剂量组CRF模型大鼠及正常健康大鼠对照组的血尿素氮、肌酐、24h尿量、尿蛋白量,以及肾组织病理变化。结果表明广东虫草子实体组能显著降低CRF大鼠血尿素氮和肌酐,能促进机体生成白蛋白和总蛋白,改善肾功能衰竭大鼠的临床症状及肾脏水肿、变大和病变程度。由此证明广东虫草子实体对大鼠的慢性肾衰竭有明显的治疗作用。Cordyceps guangdongensis is a species found in South China not long ago. It has been successfully cultivated. Previous studies indicated that the fruiting body of the fungus has noticeable effects of anti-oxidation, anti-H9N2 virus,anti-fatigue and life-prolonging, but its effect on treatment of renal disease has not yet been reported. In this study, therapeutic effects of the fungus on chronic renal failure （CRF） rats were tested. The CRF rat model was induced by feedingadenine, and the rats were divided into 6 test groups, a blank control group without any medicine treatment, a positive control group treated with a Chinese patent medicine ＇Niaoduqing＇, a normal control group of healthy rats and 3 treatment groups fed respectively with low dose, middle dose or high dose of the fruiting body of C. guangdongensis. The levels of rat blood urea nitrogen （BUN）, creatinine （Cr）, amount of emiction within 24h, urinary protein （UP） and pathological reaction of nephridialtissue were rountinely investigated with Creatinine （Cr） kit, blood urea nitrogen （BUN） kit, albumin （ALB） kit, total protein （TP） kit and urinary protein （UP） kit and standardized approaches. The results were analyzed through comparisons of the tested data from different groups of CRF rats as well as from the normal control group of healthy rats. The results showedthat feeding C. guangdongensis fruit body could improve the renal functions and reduce the BUN and Cr of the CRF rats, promote the body to generate albumin （ALB） and total protein （TP） to make up the proteins that were partially lost owing to renal damage, and alleviate the renal pathological changes of CRF rats. The conclusion can be drawn that the fruiting body ofC. guangdongensis has prominent therapeutic effects on CRF rats.

关 键 词：真菌 虫草子实体 慢性肾衰竭 药理作用 

分 类 号：R692.5[医药卫生—泌尿科学]