急性氯化氢气体中毒患者外周血淋巴细胞亚群的变化  

The changes of peripheral blood lymphocyte subsets in patients with acute hydrogen chloride gas poisoning

作　　者：吕亚莉[1] 陈传军[1] 梁碧霞[1] 

机构地区：[1]浙江省新昌县人民医院血液肿瘤科,312500

出　　处：《中华劳动卫生职业病杂志》2012年第5期375-376,共2页Chinese Journal of Industrial Hygiene and Occupational Diseases

摘　　要：目的探讨急性氯化氢气体中毒患者外周血淋巴细胞亚群的变化，为临床治疗提供依据。方法采用美国BD公司生产的FACSCalibur流式细胞仪检测37例急性氯化氢气体中毒患者入院当日或次13淋巴细胞亚群总T细胞（CD3＋CD19-）、CD4＋T细胞（CD3＋CD4＋）、CD8＋T细胞（CD3＋CD8＋）、B细胞（CO3-CO19＋）和NK细胞（CD3＋CD16＋CD56＋）百分数及CD4＋／CD8＋比值；并与健康体检的49名健康人进行对照分析。观察淋巴细胞亚群的变化。结果急性氯化氢气体中毒患者总T细胞百分数及CD4＋T细胞百分数明显低于健康组，差异有统计学意义（P〈0．05）；CD8＋T细胞百分数与健康组的差异无统计学意义（P〉0．05）；NK细胞及B淋巴细胞百分数明显高于健康组，差异有统计学意义（P〈0．05）；CD4＋/CD8＋比值明显低于健康组，差异有统计学意义（P〈0．05）。结论急性氯化氢气体中毒患者外周血淋巴细胞亚群水平存在异常．提示急性氯化氢气体中毒患者免疫功能受到影响。Objective To explore the changes of peripheral blood lymphocyte subsets in patients with acute hydrogen chloride gas poisoning. Methods When the patients were admitted or on the secondary day, the percentages of total T-cell lymphocyte subsets （CD3＋CD19＋）, CD4＋ T cells （CD3＋CD4＋）, CD8＋ T cells （CD3＋ CDs＋）, B cells （CD3-CD19＋） and NK cells （CD3-CD16＋ CD56＋） , and the ration of CD4＋/CDs＋ in 37 cases with acute hydrogen chloride gas poisoning and 49 healthy controls were detected with flow cytometer. Results The total T-cell percentage and total CD4＋T cell percentage in 37 cases were significantly lower than those in 47 controls （P〈0.05）. The percentages of NK cells and B lymphocytes in 37 cases significantly increased, as compared with controls （P〈0.05）. The ration of CD4＋/CD8＋ in 37 cases significantly decreased, as compared with controls （P〈O.05）. Conclusion The lymphocyte subsets in the patients with acute hydrogen chloride gas poisoning changed, which could influence the immune function of patients.

关 键 词：气体中毒 氯化氢 急性 淋巴细胞亚群 

分 类 号：R595.1[医药卫生—内科学]