醒脑静注射液对急性酒精中毒大鼠抗氧化作用的干预研究  

Intervention Study of Antioxidation Effect in Xingnaojing Injection on Acute Alcohol Intoxication

作　　者：张宇[1] 邸智勇[1] 胡慧静[1] 马晨光[1] 

机构地区：[1]黑龙江省医院,黑龙江哈尔滨150036

出　　处：《中国中医急症》2012年第5期727-728,共2页Journal of Emergency in Traditional Chinese Medicine

基　　金：黑龙江省青年科学基金项目(QC2010055)

摘　　要：目的观察醒脑静注射液对急性酒精中毒大鼠抗氧化作用的干预作用。方法将80只月龄为8～10周的SD雄性大鼠,体质量240～260 g,禁食12 h处理后分别灌胃醒脑静注射液和生理盐水,30 min后按照16 mL/kg用50%酒精灌胃。灌胃60 min后以翻正反射消失为指标判断大鼠急性酒精中毒模型。比较两组大鼠酒精耐受时间和醉酒时间;分别测定血浆氧自由基和超氧化物歧化酶的水平及血浆中乙醇的含量。结果醒脑静注射液能够延长急性酒精中毒大鼠的酒精耐受时间、缩短醉酒时间;实验组氧化程度有明显降低。结论醒脑静注射液对急性酒精中毒大鼠有保护和抗氧化作用。Objective： To research the intervention effect of Xingnaojing Injection on acute alcohol intoxication.Methods：After fasting for 12h,the acute alcohol intoxication model was made by 50% alcohol for 60 min.These rats were divided randomly into the treatment group with the Xingnaojing Injection and the control group with the normal saline.The alcohol tolerance time,the drunk shorten time,the SOD level and the alcohol concentration were detected after treatment.Results：In the treatment group,the alcohol tolerance time was prolong and the drunk shorten time was shorten.Meanwhile,the oxidation degree in this group was reduced obviously.Conclusion：The Xingnaojing Injection has the protection and the antioxidation effect.

关 键 词：醒脑静注射液 急性酒精中毒 氧自由基 超氧化物歧化酶 

分 类 号：R285.5[医药卫生—中药学]