瑞舒伐他汀钙对冠心病患者外周血内皮前体细胞水平的干预作用  

Effect of rosuvastatin on endothelial progenitor cells in peripheral blood of patients with coronary heart disease

作　　者：郭文静[1] 李晓燕[2] 张红明[2] 韩淑芳[2] 康玲[3] 

机构地区：[1]辽宁医学院 济南军区总医院研究生培养基地,济南250031 [2]济南军区总医院,济南250031 [3]泰山医学院附属医院,泰安271000

出　　处：《军医进修学院学报》2012年第6期596-598,共3页Academic Journal of Pla Postgraduate Medical School

摘　　要：目的观察瑞舒伐他汀钙片对冠心病患者外周血CD34与VEGFR-2(血管内皮生长因子-2)共同标记的血管内皮前体细胞CD34+/VEGFR-2+EPCs水平的影响,进一步研究他汀类的非调脂作用。方法选取经皮冠状动脉造影检查明确诊断的冠心病患者112例,按结果分为单支病变组(37例)、双支病变组(36例)、三支病变组(39例),给予瑞舒伐他汀钙片(10mg1/晚)治疗。治疗前及治疗1月后,流式细胞仪检测外周血CD34+/VEGFR-2+EPCs在全血中所占的比例。结果 1)瑞舒伐他汀钙片干预1月后,血浆中总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-CH)与干预前相比均有显著性下降(P<0.001),甘油三酯(TG)与干预前相比,呈下降趋势(P<0.05),高密度脂蛋白胆固醇(HDL-C)变化无统计学意义(P>0.05);2)随着冠脉病变加重,外周血CD34+/VEGFR-2+EPCs含量逐渐减少(P<0.05);3)在冠状动脉同一病变程度上,冠心病患者外周血中CD34+/VEGFR-2+EPCs水平较用药前明显上升(P<0.05)。结论他汀类药物除具有较好的调脂作用外,还可以提升外周血中循环内皮前体细胞的数量,有利于减慢冠状动脉粥样硬化进程。Objective To study the lipid-regulating function of rosuvastatin by observing its effect on endothelial prognostic cells（EPC） marked by CD34＋ and vascular endothelial growth factor-2＋（VEGFR-2＋） in peripheral blood of patients with coronary heart disease（CHD）.Methods One hundred and twelve patients with CHD diagnosed by percutaneous coronary angiography were divided into single-vessel lesion group（n=37）,double-vessel lesion group（n=36） and triple-vessel lesion group（n=39）.The patients were treated with 10mg rosuvastatin calcium,once a night.The number of EPC marked with CD34＋ and VEGFR-2＋ was detected by flow cytometry 1 month before and after treatment.Results The TC and LDL-CH levels were significantly lower 1 month after treatment than before treatment（P0.001）.The TG level was lower after treatment than before treatment（P0.05）,but no significant difference was observed in HDL-CH level（P0.05）.The number of EPC marked with CD34＋ and VEGFR-2＋ decreased gradually with the aggravation of CHD（P0.05） and was significantly higher in CHD patients after treatment than before treatment（P0.05）.Conclusion Rosuvastatin can increase the number of EPC in peripheral blood of CHD patients,besides its good lipid-regulating function,thus slowing down the coronary atherosclerotic process.

关 键 词：冠心病 CD34+/VEGFR-2+血管内皮前体细胞 流式细胞术 瑞舒伐他汀钙片 

分 类 号：R541.4[医药卫生—心血管疾病]