25羟维生素D与高血压关系的荟萃分析  

Meta-analysis on the relationship between 25-hydroxyvitamin D level and hypertension

作　　者：刘奕婷[1] 蔡云飞[1] 时景璞[1] 

机构地区：[1]中国医科大学附属第一医院临床流行病教研室辽宁省循证医学中心,沈阳110001

出　　处：《中华医学杂志》2012年第18期1268-1271,共4页National Medical Journal of China

摘　　要：目的探讨25羟维生素D与高血压之间的关系，为高血压的防治和病因探索提供依据。方法检索国内外各类大型数据库中近11年发表的有关25羟维生素D与高血压关系的文献，采用荟萃分析的方法，利用Stata11．0软件评价25羟维生素D与高血压之间的关系。结果荟萃分析表明25羟维生素D缺乏者发生高血压的危险性是25羟维生素D充足者的1．37倍（95％CI1．23～1．53）。按照25羟维生素D水平〈35nmoL／L和35～68nmol／L进行亚组分析得出，在〈35nmol／L组，25羟维生素D缺乏者发生高血压的危险性为2．02倍（95％CI1．49～2．74），差异有统计学意义（P〈0．05）。在35—68nmol／L组，25羟维生素D缺乏者发生高血压的危险性为1．23倍（95％CI1．02～1．49），差异有统计学意义（P〈0．05）。结论25羟维生素D与高血压发病之间有联系。Objective To explore the association between 25-hydroxyvitamin D level and hypertension so as to provide rationales for developing preventive strategies and understanding the etiology of hypertension. Methods The articles on the association of 25-hydroxyvitamin D level and hypertension were retrieved by searching international and national databases from 2000 to 2011. The relationship between 25- hydroxyvitamin D level and hypertension was assessed by Meta-analysis with Statal 1.0 software. Results The results of Meta analysis showed that the pooled OR values of hypertension with 25-hydroxyvitamin D level deficiency and sufficiency was 1.37 （ 95% CI 1.23 - 1.53 ） . Subgroup analysis revealed in 25- hydroxyvitamin D level, can be drawn between 25-hydroxyvitamin D level and the incidence of hypertension was statistically significant. The pooled OR values of hypertension with 25-hydroxyvitamin D level in 35 nmol/L and 35 -68 nmol/L were 2. 02 （95% CI 1.49 - 2. 74） and 1.23 （95% CI 1.02 - 1.49） （P 〈 0. 05）. Conclusions The 25-hydroxyvitamin D level is associated with hypertension. With regards to the question of whether or not the 25-hydroxyvitamin D level deficiency serves as one of the potential risk factor for hypertension, prospective studies of larger sample sizes are warranted.

关 键 词：高血压 META分析 25羟维生素D 

分 类 号：R544.1[医药卫生—心血管疾病]