慢性阻塞性肺疾病急性加重期并发呼吸衰竭病人肠内营养联合生长激素的疗效观察  

The effect of the early enteral nutrition and growth hormone in the patients with Acute exacerbation of chronic obstructive pulmonary disease and respiratory failure

作　　者：肖小荣 张宇[1] 陈露[1] 陈晓宇[1] 罗金明[1] 

机构地区：[1]台州市第一人民医院重症医学科,浙江台州318020

出　　处：《肠外与肠内营养》2012年第3期139-141,共3页Parenteral & Enteral Nutrition

摘　　要：目的:探讨早期肠内营养(EEN)联合重组人生长激素(rhGH)对慢性阻塞性肺疾病急性加重期(AECOPD)并发呼吸衰竭的疗效。方法:将90例AECOPD病人随机分为试验组和对照组,每组45例。对照组病人给予常规临床治疗,试验组病人在此基础上给予EN联合皮下注射GH,观察两组病人机械通气时间,检测两组病人治疗期间营养指标、免疫指标和T细胞亚群等。结果:试验组病人治疗后1周的血清清蛋白、转铁蛋白、前清蛋白、血红蛋白、纤维连接蛋白、免疫球蛋白和T细胞亚群均明显高于对照组(P<0.05),机械通气时间明显缩短(P<0.05),病死率减低(P<0.05)。结论:EN联合GH治疗不仅能缩短AECOPD并发呼吸衰竭病人机械通气时间,而且还能改善病人营养状况,增强免疫功能,提高临床疗效。Objective： To explore the effect of the early enteral nutrition and recombinant human growth hormone（rhGH） to the patients with acute exacerbation of chronic obstructive pulmonary disease（AECOPD） and respiratory failure.Methods： 90 patients with acute exacerbation of chronic obstructive pulmonary disease were randomly divided into experimental group（EN＋rhGH）（n=45）and control group（n=45）.The experimental group received the enteral nutrition and rhGH and the control group received the regular clinical therapy.The mechanical ventilation time was observed.The blood biochemical indexes,nutritional indexes immune indexes and T cell subset indexes in the period of treatment were examined in two groups.Results： In the experimental group,the albumins,transferrin,prealbumin,hemoglobin,fibronection,IgA and T cell subset were significantly higher than that of control group（P0.05）after a week,the mechanical ventilation time was shorter（P0.05）,and mortality rate was lower（P0.05）.Conclusion： Early enteral nutritional and rhGH can not only shorten the mechanical ventilation time,but also improve nutritional status and clinical effect in AECOPD patients.

关 键 词：慢性阻塞性肺疾病 呼吸衰竭 肠内营养 生长激素 

分 类 号：R563.9[医药卫生—呼吸系统]