结直肠癌与不同上皮内瘤变腺瘤中PI3Kp110β的表达及临床意义  

Expression and clinical significance of PI3Kp110β in human colorectal carcinoma and colorectal adenoma with different grades of dysplasia

作　　者：高向前[1] 吴淑华[1] 李扬扬[2] 曹璋[1] 纪洪[2] 

机构地区：[1]滨州医学院病理学教研室,滨州256603 [2]滨州医学院附属医院病理科,滨州256603

出　　处：《临床与实验病理学杂志》2012年第5期518-521,共4页Chinese Journal of Clinical and Experimental Pathology

摘　　要：目的探讨PI3Kp110β表达与结直肠癌发生、发展的相关性及其临床意义。方法应用免疫组化EnVision法检测PI3Kp110β在138例结直肠腺癌、29例低级别上皮内瘤变(low-grade intraepithelial neoplasia,LGIN)腺瘤、35例高级别上皮内瘤变(high-grade intraepithelial neoplasia,HGIN)腺瘤、10例结肠正常黏膜组织中的表达情况。结果 (1)PI3Kp110β在结直肠癌组织中的表达明显高于结直肠LGIN腺瘤、HGIN腺瘤及正常黏膜组织,其差异有统计学意义(P<0.05),PI3Kp110β在结直肠HGIN腺瘤组织中的表达与结直肠LGIN腺瘤、正常黏膜组织中的表达相比,差异无显著性(P>0.05);(2)结直肠癌组织中PI3Kp110β的表达与肿瘤的发生部位、分化程度、临床分期及淋巴结转移等临床因素间具有相关性(P<0.05),与患者的性别、年龄及肿瘤大小等因素无关(P>0.05)。结论 PI3Kp110β异常表达可能在结直肠癌的发生、发展中发挥着重要作用,检测PI3Kp110β对评判结直肠癌的生物学行为及预后有一定临床意义。Purpose To investigate PI3Kp110β expression in the occurrence and the development of human colorectal carcinoma and discuss its clinical significance. Methods The expression of PI3Kp110β was detected in 138 cases of adenocarcinoma, 29 cases of low-grade intraepithelial neoplasia, 35 cases of high-grade intraepithelial neoplasia, and 10 cases of normal mueosa by EnVision immu- nohistochemical method. Results （1）The expression of PI3Kp11013 in adenocarcinoma was higher than those in adenoma with low- grade intraepithelial neoplasia, adenoma with high-grade intraepithelial neoplasia, normal mucosa which was significantly difference （P 〈 0. 05 ）. （ 2 ） The expression of PI3 Kp110β was closely correlated with the location, differentiation, metastasis and TNM staging （ P 〈 0.05 ）, hut unrelated to gender, age and size of the tumour（ P 〉 0.05 ）. Conclusions PI3Kp110β may play an important role in the development or progression of colorectal carcinoma.

关 键 词：结直肠肿瘤 上皮内瘤变 腺瘤 PI3Kp110β 临床意义 

分 类 号：R392.1[医药卫生—免疫学]