甲状腺自身抗体对妊娠结局和后代的影响及干预  

Thyroid autoantibodies： adverse effects on pregnancy outcomes and child development and its intervention

作　　者：刘海霞[1] 单忠艳[2] 

机构地区：[1]大连医科大学附属第二医院内分泌科 [2]中国医科大学附属第一医院内分泌科；省部共建辽宁省内分泌疾病国家重点实验室培育基地,沈阳110001

出　　处：《中华内分泌代谢杂志》2012年第5期441-444,共4页Chinese Journal of Endocrinology and Metabolism

基　　金：国家973计划前期研究专项（2011CB512112）;国家自然科学基金项目（81170730）

摘　　要：母体甲状腺功能正常、单纯甲状腺自身抗体阳性可以导致不良的妊娠结局，如流产、早产等，使妊娠妇女和新生儿的TSH常高于正常参考范围上限，并影响后代智力发育。甲状腺自身抗体对妊娠结局和后代影响的机制尚未阐明，干预主要为左旋甲状腺素与硒制剂。本文就当前甲状腺自身免疫对妊娠结局与后代的影响以及干预作一综述。Thyroid autoantibodies （TAA） in euthyroid women were associated with several adverse pregnancy outcomes, such as miscarriage, preterm birth. Maternal TAA frequently results in transient mild elevation of serum TSH above the normal reference value in women during pregnancy and in infants born in the first month of life, and may affect neuropsychological development of their offspring. The cause is still unclear. Medical interventions on TAA involve levothyroxine or selenium supplementation. The article reviews the effects of maternal thyroid autoantibodies on pregnancy outcomes, as well as on neonatal thyroid status, and neuropsychological development of the fetus and neonate, and summarizes therapeutic strategies used to intervene maternal thyroid autoimmunity.

关 键 词：甲状腺自身抗体 自身免疫 妊娠结局 干预 

分 类 号：R714.2[医药卫生—妇产科学]