恶性黑棘皮病并发Leser-Trélat征1例  

A Case of Malignant Acanthosis Nigricans with Leser-Trélat Sign

作　　者：孙健[1] 李东宁[1] 杨静[2] 

机构地区：[1]辽宁医学院附属第一医院皮肤性病科,辽宁锦州121001 [2]辽宁医学院附属第一医院病理科,辽宁锦州121001

出　　处：《中国皮肤性病学杂志》2012年第6期534-535,547,共3页The Chinese Journal of Dermatovenereology

摘　　要：患者男,72岁。全身褶皱部、乳晕肥厚、色素沉着3个月,周身泛发性丘疹伴剧痒2个月。皮肤科情况:颈部、腋窝、腹股沟、肛周皮肤肥厚、色素沉着,呈绒毛状或乳头瘤样增生,双侧乳头和乳晕角化、色素沉着,颈部、躯干及四肢散在米粒至黄豆大肤色至淡褐色角化性丘疹及斑丘疹。皮损组织病理示(上胸部):表皮角化过度,棘层肥厚,乳头瘤样增生,基底层色素增加;(右侧腹股沟):表皮中度角化过度,乳头瘤样增生,乳头似指样向上凸出,棘层中度肥厚,基底层色素增加,真皮浅层少许淋巴细胞浸润。诊断:恶性黑棘皮病并发Leser-Trélat征。A 72-year-old male patient had presented with thickening and hyperpigmentation on his intertriginous regions over the body and his mammae areolae for three months,extensive papules all over the body for two months accompanied with itching.Physical examination showed the skin of the neck,axillae,groins and perianal region dermatauxe and hyperpigmentation with villous or papillomatous hyperplasia,the nipples and mammae areolae keratinization and hyperpigmentation.There were many keratotic papules and maculopapules on his neck,trunk and limbs,in sizes of grain or soybean,in color of skin or brown.Histopathological examination of upper breast skin showed hyperkeratosis,acanthosis in the epidermis,papillomatous hyperplasia,stratum basale pigmentation.Histopathological examination of right inguinal areas showed moderate hyperkeratosis,papillomatous hyperplasia,moderate acanthosis,stratum basale pigmentation,superficial dermal infiltrated by a few of lymphocytes.The case was finally diagnosed as malignant acanthosis nigricans with Leser-Trélat sign.

关 键 词：黑棘皮病 恶性 Leser-Trélat征 

分 类 号：R751[医药卫生—皮肤病学与性病学]