白细胞过滤时机对于血小板输注效果影响的Meta分析  

Effect of Leukocyte-Filtered Time on Platelet Transfusion： A Meta-Analysis

作　　者：张杰[1] 陈雪[1] 袁强[2] 成岚[2] 傅雪梅[1] 李幼平[2] 王乃红[1] 王莉[2] 周昌华[1] 

机构地区：[1]成都市血液中心血液研究实验室, 成都610041 [2]四川大学华西医院中国循证医学中心,成都610041

出　　处：《国际输血及血液学杂志》2012年第3期195-197,共3页International Journal of Blood Transfusion and Hematology

基　　金：四川省医学重点实验室建设项目;成都市卫生局2009年青年基金科研课题（编号0916,0917）

摘　　要：目的系统评价WBC过滤时机对于血小板（PLT）输注效果的影响。方法计算机检索Pubmed，EMBASE，Cochrane图书馆和中国生物医学文献数据库，检索年限从建库至2011年12月。纳入比较保存前与保存后过滤WBC的PLT输注效果的临床试验相关文献。采用RevMan5．0软件进行Meta分析。结果共纳入4篇相关研究的文献。Meta分析结果显示：与输注保存前过滤WBC的PLT相比，输注保存后过滤WBC的PLT的24h血小板计数增加校正值（CCI）比较，差异无统计学意义[MD=-0．58，95％CI（-1．75，0．58），P=0．33]，不良反应发生率比较，差异无统计学意义[RR=0．76，95％CI（O．56，1．03），P=0．07]。结论WBC过滤时机对于PLT输注后24hCCI值和不良反应发生率无影响。Objective To systematically assess the effect of leukocyte-filtered time on platelet transfusion. Methods The databases of Pubmed, EMBASE, Cochrane Library and CBM were searched to select the clinical trials of pre-storage and post-storage leukocyte-filtered platelet transfusion from their establishment to December 2011. Meta-analysis was conducted by Cochrane Collahoration^s RevMan 5.0 software. Results A total of 4 studies were selected to further Meta-analysis. The data showed that post- storage leukocyte-filtered platelet transfusion was no significant difference in 24 h corrected count increment （CCI） [MD=- -0.58,95%CI （-1.75,0.58）, P=0.33],and no statistic difference in adverse event [RR= 0.76,95%CI （0. 56, 1. 03）, P= 0. 07] compared to pre-storage leukocyte-filtered platelet transfusion. Conclusions The results suggest that leukocyte-filtered time has no effect on 24 h CCI and adverse event in platelet transfusion.

关 键 词：WBC过滤 PLT输注 META分析 

分 类 号：R457.1[医药卫生—治疗学]