表现为皮肤大片瘀斑和坏死的抗磷脂抗体综合征  

A case of antiphospholipid syndrome(APS)presenting with large areas of ecchymosis and necrosis on skin

作　　者：夏济平[1] 许阳[1] 侯麦花[1] 张美华[1] 

机构地区：[1]南京医科大学第一附属医院皮肤性病科,江苏南京210029

出　　处：《临床皮肤科杂志》2012年第6期363-365,共3页Journal of Clinical Dermatology

摘　　要：报告1例表现为皮肤大片瘀斑和坏死的抗磷脂抗体综合征。患者女性,42岁。双侧臀部及下肢大片瘀斑、坏死,血小板减少,抗核抗体、抗心磷脂抗体异常升高,补体降低。皮损组织病理示真皮血管有血栓存在。给予抗凝、血管扩张剂、糖皮质激素、免疫抑制剂和静脉注射用人免疫球蛋白等控制病情的同时,外科手术修复大片坏死皮肤。A case of antiphospholipid syndrome （APS） presenting with large areas of ecchymosis and necrosis on skin is reported. A 42-year-old female suffered from skin ecchymosis and necrosis in buttocks and lower limbs with thrombocytopenia, abnormal elevation of ANA and antiphospholipid antibodies （APL）, and low complements. Histopathology revealed thrombosis of dermal and subcutaneous vessels. As treatment with anticoagulation, vasodilation, immunosuppressant, intravenous immunoglobulin, the condition of the patient was changed successfully. And then the effective surgical treatment restored the large area of the necrotic skin.

关 键 词：抗磷脂抗体综合征 瘀斑 坏死 

分 类 号：R593.2[医药卫生—内科学]