右心房注射缓激肽对未成年大鼠呼吸的影响  

Effect of Injection with Bradykinin in Atrium Dextrum on Respiration in Neonatal Rats

作　　者：张翔[1] 孙明洁[2] 基鹏[1] 刘斌[1] 王儒蓉[1] 

机构地区：[1]四川大学华西医院麻醉科,成都610041 [2]青岛市人民医院麻醉科

出　　处：《华西医学》2012年第4期549-551,共3页West China Medical Journal

摘　　要：目的探讨在Sprague-Dawley大鼠右心房注射缓激肽对呼吸的影响。方法 7～9 d和21～23 d大鼠在迷走神经完整和迷走神经切断的情况下从右心房注射缓激肽,观察呼吸指标的变化。结果①右心房注射缓激肽后,7～9 d大鼠出现呼吸暂停,而在21～23 d大鼠仅出现呼吸抑制(P<0.05);②切断迷走神经后,右心房注射缓激肽在两组大鼠均不再出现呼吸暂停。结论右心房注射缓激肽在7～9 d大鼠产生呼吸暂停,且依赖于迷走神经的完整性。Objective To explore the effect of ijection with bradykinin in atrium dextrum on respiration in neonatal Sprague-Dawley（SD） rats at different age.Methods SD rats at postnatal day 7-9（P7-9） and 21-23（P21-23） with intact or transected bilateral vagus received injection with bolus bradykinin in atrium dextrum.The ventilatory alterations were compared between groups.Results ① Injection with bradykinin in atrium dextrum led to apnea in P7-9 rats,but induced mild breathing inhibition in P21-23 rats（P〈0.05）.② After the transection of bilateral vagus,the bradykinin did not induce apnea in both groups.Conclusion Injection with bradykinin in atrium dextrum may induce apnea in neonatal rats,which depends on the integrality of vagus.

关 键 词：缓激肽 迷走神经 呼吸暂停 新生期 

分 类 号：R614[医药卫生—麻醉学]