2型糖尿病合并不稳定性心绞痛患者尿微量白蛋白、血浆内皮素与冠脉病变程度的关系研究  

Relationship Between Microalbuminuria and Plasma Endothelin and Severity of Coronary Artery Disease in Patients with Type 2 Diabetes Mellitus Angina

作　　者：郑巨克[1] 李星群[1] 潘嘉西[1] 章敏学[1] 

机构地区：[1]温州医学院附属第三医院心内科,瑞安325200

出　　处：《医学研究杂志》2012年第5期153-155,共3页Journal of Medical Research

摘　　要：目的探讨2型糖尿病合并不稳定性心绞痛患者尿微量白蛋白(MA)和血浆内皮素(ET)与冠脉病变程度的关系。方法通过将笔者医院2009年1月～2011年1月住院治疗的85例不稳定性心绞痛患者依据冠脉病变支数和Gensini积分进行分组,并分析MA和ET与冠脉病变支数及Gensini积分相关性。结果①多支病变组(≥2支)共有69例患者,占81.2%,单支病变组16例患者,占18.8%;严重病变组(即Gensini积分﹥20分)共有53例患者,占62.4%,非严重病变组(即Gensini积分0～20分)32例患者,占37.6%;②单支病变组的ET水平(72.32±7.34pg/ml vs 81.47±5.65pg/ml,P<0.05)和MA水平(23.46±1.15mg/L vs 35.21±4.23mg/L,P<0.01)均低于多支病变组,非严重病变组的ET水平和MA水平均低于严重病变组(P<0.01和P<0.05);③2型糖尿病合并不稳定性心绞痛患者ET水平和MA水平与Gensini积分具有显著相关性(r=0.75,P<0.05和r=0.63,P<0.05)。结论 2型糖尿病合并不稳定性心绞痛患者的尿微量白蛋白和血浆内皮素与冠脉病变程度有显著性的正相关,随着冠脉病变程度的加重,其尿微量白蛋白和血浆内皮素的水平升高。Objective To explore the relationship between mieroalbuminuria （MA） and endothelin （ET） and degree of coronary stenosis in patients with type 2 diabetes mellitus and unstable angina. Methods Totally 85 patients treated in our hospital from January 2009 to January 2011 were divided into groups according to the number of coronary vessels disease and coronary Gensini score. Then, the relevance between level of MA and ET with the number of coronary vessels disease and coronary Gensini score was analyzed. Results （1） There were 69 patients （81.2%） in multi -vessel stenosis group and 16 patients （18.8%） in one -vessel stenosis group. Mean while, there were 53 patients （62.4%） in advanced lesions group（ Gensini Score 〉 20） and 32 patients （37.6%） in non - advanced lesions group （ Gensini Score 0 - 20）. （2） The ET （ 72.32 ± 7.34pg/ml vs 81.47± 5.65 pg/ml, P 〈 0.05 ） and MA （ 23.46 ±1.15mg/L vs 35.21 ±4.23 mg/L, P 〈 0. O1 ） level of one -vessel stenosis group were lower than the multivessel stenosis group with a significant difference. The ET （P 〈 0.01 ） and MA （P 〈 0.05 ） level of nonadvanced lesions group were lower than advanced lesions group. （3） There were significant relevance between ET （ r = 0.75, P 〈 0.05 ） and MA （ r = 0.63,P 〈 0.05 ） level with Gensini score in patients with type 2 diabetes mellitus and unstable angina. Conclusion There was significant relevance between ET and MA level with severity of coronary artery disease in patients with type 2 diabetes mellitus and unstable angina. With the development of severity of coronary artery disease, the ET and MA level elevated.

关 键 词：2型糖尿病尿微量白蛋白 血浆内皮素冠脉病变程度Gensini积分 

分 类 号：R541.4[医药卫生—心血管疾病]